(2R,6R)-Hydroxynorketamine hydrochloride (Synonyms: (2R,6R)-HNK hydrochloride)

Name: (2R,6R)-Hydroxynorketamine hydrochloride
Brand: MedChemExpress
SKU: HY-101955A
Rating: 4.5 (1 reviews)

Cat. No.: HY-101955A Purity: 99.61%: Data Sheet
SDS

COA
Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

(2R,6R)-Hydroxynorketamine (hydrochloride) is an active molecule with a neurorelaxing effect..

For research use only. We do not sell to patients.

(2R,6R)-Hydroxynorketamine hydrochloride Chemical Structure

CAS No. : 1430202-69-9

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of (2R,6R)-Hydroxynorketamine hydrochloride:

(2S,6S)-Hydroxynorketamine hydrochloride Get quote

Biological Activity
Purity & Documentation
References
Customer Review

Description

(2R,6R)-Hydroxynorketamine (hydrochloride) is an active molecule with a neurorelaxing effect.^[1].

Molecular Weight

276.16

Formula

C₁₂H₁₅Cl₂NO₂

CAS No.

1430202-69-9

Appearance

Solid

Color

Off-white to yellow

SMILES

N[C@@]1(C([C@@H](CCC1)O)=O)C2=C(C=CC=C2)Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (362.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6211 mL	18.1054 mL	36.2109 mL
5 mM	0.7242 mL	3.6211 mL	7.2422 mL
10 mM	0.3621 mL	1.8105 mL	3.6211 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (9.05 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Purity & Documentation

Purity: 99.61%

Select Batch:

Data Sheet (279 KB) SDS (393 KB)

COA (259 KB) HNMR (265 KB) LCMS (89 KB)

Handling Instructions (2659 KB)

References

[1]. Yang C, et al. (R)-Ketamine Shows Greater Potency and Longer Lasting Antidepressant Effects Than Its Metabolite (2R,6R)-Hydroxynorketamine. Biol Psychiatry. 2017 Sep 1;82(5):e43-e44. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.6211 mL	18.1054 mL	36.2109 mL	90.5272 mL
	5 mM	0.7242 mL	3.6211 mL	7.2422 mL	18.1054 mL
	10 mM	0.3621 mL	1.8105 mL	3.6211 mL	9.0527 mL
	15 mM	0.2414 mL	1.2070 mL	2.4141 mL	6.0351 mL
	20 mM	0.1811 mL	0.9053 mL	1.8105 mL	4.5264 mL
	25 mM	0.1448 mL	0.7242 mL	1.4484 mL	3.6211 mL
	30 mM	0.1207 mL	0.6035 mL	1.2070 mL	3.0176 mL
	40 mM	0.0905 mL	0.4526 mL	0.9053 mL	2.2632 mL
	50 mM	0.0724 mL	0.3621 mL	0.7242 mL	1.8105 mL
	60 mM	0.0604 mL	0.3018 mL	0.6035 mL	1.5088 mL
	80 mM	0.0453 mL	0.2263 mL	0.4526 mL	1.1316 mL
	100 mM	0.0362 mL	0.1811 mL	0.3621 mL	0.9053 mL

(2R,6R)-Hydroxynorketamine hydrochloride Related Classifications

Neurological Disease

Keywords:

(2R,6R)-Hydroxynorketamine1430202-69-9(2R,6R)-HNKEndogenous MetaboliteInhibitorinhibitorinhibit

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(2R,6R)-Hydroxynorketamine hydrochloride (Synonyms: (2R,6R)-HNK hydrochloride)

Customer Review

Other Forms of (2R,6R)-Hydroxynorketamine hydrochloride:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

(2R,6R)-Hydroxynorketamine hydrochloride Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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