2. Metabolic Enzyme/Protease Apoptosis NF-κB Immunology/Inflammation
  3. Endogenous Metabolite Apoptosis Reactive Oxygen Species
  4. β-Carotene

β-Carotene  (Synonyms: Provitamin A; beta-Carotene)

Cat. No.: HY-N0411 Purity: 98.82%
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β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities.

For research use only. We do not sell to patients.

β-Carotene Chemical Structure

β-Carotene Chemical Structure

CAS No. : 7235-40-7

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Based on 1 publication(s) in Google Scholar

Other Forms of β-Carotene:

β-Carotene Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE β-Carotene

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities[1][2][3][4][5].

IC50 & Target[3]

Human Endogenous Metabolite

 

apoptosis

 

In Vitro

β-Carotene up-regulates PPAR-γ expression and ROS production in MCF-7 cancer cells[3].
β-Carotene (1-100 μM; 72 hours) remarkably decreases the survival of MCF-7 cells in a dose-dependent manner[3].
β-Carotene (50 μM; 24-72 hours) significantly enhances the expression levels of PPAR-γ mRNA and protein in a time-dependent manner[3].
β-Carotene down-regulates the COX-2 but up-regulates the p21 mRNA level and protein expression in a time dependent manner[3].
β-Carotene significantly increases the percentage of early apoptosis and the effect was partly attenuated by pre-incubation with GW9662 (HY-16578) or GSH (HY-D0187)[3].
β-Carotene induces cytochrome C release[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-Carotene Related Antibodies

Cell Viability Assay[5]

Cell Line: MCF-7 cells
Concentration: 1 μM, 10 μM, 20 μM, 50 μM, 100 μM
Incubation Time: 72 hours
Result: Decreased the numbers of viable cells to 70% and 50% at 20 μM and 50 μM, respectively.

RT-PCR[5]

Cell Line: MCF-7 cells
Concentration: 50 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Up-regulated the PPAR-γ mRNA.

Western Blot Analysis[5]

Cell Line: MCF-7 cells
Concentration: 50 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Up-regulated PPAR-γ protein expression levels.

Apoptosis Analysis[5]

Cell Line: MCF-7 cells
Concentration: 50 μM
Incubation Time: 72 hours
Result: Induced MCF-7 cells apoptosis.
Clinical Trial
Molecular Weight

536.87

Formula

C40H56
CAS No.
Appearance

Solid

Color

Brown to red

SMILES

CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)=C(C)CCC1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

THF : 10 mg/mL (18.63 mM; ultrasonic and warming and heat to 60°C)

DMSO : 1 mg/mL (1.86 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8626 mL 9.3132 mL 18.6264 mL
5 mM 0.3725 mL 1.8626 mL 3.7253 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  15% Cremophor EL    85% Saline

    Solubility: 10 mg/mL (18.63 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.82%

COA (241 KB) HNMR (262 KB) RP-HPLC (191 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / THF 1 mM 1.8626 mL 9.3132 mL 18.6264 mL 46.5660 mL
THF 5 mM 0.3725 mL 1.8626 mL 3.7253 mL 9.3132 mL
10 mM 0.1863 mL 0.9313 mL 1.8626 mL 4.6566 mL
15 mM 0.1242 mL 0.6209 mL 1.2418 mL 3.1044 mL
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β-Carotene Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Carotene7235-40-7Provitamin A beta-CaroteneEndogenous MetaboliteApoptosisReactive Oxygen Speciesperoxisomeproliferator-activatedreceptorγPPAR-γactivationROSproductionp21COX-2antioxidantprooxidantInhibitorinhibitorinhibit

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