Etentamig (Synonyms: ABBV-383; TNB 383B)

Cat. No.: HY-P990785 Purity: 99%: Data Sheet
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Etentamig is a BCMA × CD3 bispecific T-cell engager (BiTE) that can inhibit the activity of B-cell maturation antigen (BCMA) and activate the T-cell surface glycoprotein CD3 complex. Etentamig can be used for research in multiple myeloma, immunoglobulin light chain amyloidosis, and cardiovascular diseases.

For research use only. We do not sell to patients.

CAS No. : 2490552-52-6

Size	Price	Stock	Quantity
1 mg	USD 750	Get quote	Estimated Time of Arrival: April 22
5 mg	USD 2100	In-stock	Estimated Time of Arrival: April 22
10 mg		Get quote
50 mg		Get quote

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Description	Etentamig is a BCMA × CD3 bispecific T-cell engager (BiTE) that can inhibit the activity of B-cell maturation antigen (BCMA) and activate the T-cell surface glycoprotein CD3 complex. Etentamig can be used for research in multiple myeloma, immunoglobulin light chain amyloidosis, and cardiovascular diseases^[1].
Isotype	Human IgG4 kappa
Recommend Isotype Controls	Human IgG4 (S228P) kappa, Isotype Control
Molecular Weight	123800.00
CAS No.	2490552-52-6
Appearance	Liquid
Color	Colorless to light yellow
SMILES	[Etentamig]
Shipping	Shipping with dry ice.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Format	G4_L-kappa_VH-VH-h-CH2-CH3
Biological Activity	Loaded ABBV-383 on AHC2 biosensor, can bind BCMA/TNFRSF17 Protein, Human (HEK293, His, HY-P72847) with an affinity constant of 1.731E-11 M as determined in BLI assay. Loaded ABBV-383 on AHC2 biosensor, can bind CD3D-CD3E Heterodimer Protein, Human (HEK293, Fc-Flag&Fc-His, HY-P70434) with an affinity constant of 3.674E-07 M as determined in BLI assay.
Purity & Documentation	Purity: 99% Select Batch: Data Sheet (256 KB) SDS (251 KB) COA (232 KB) Inhibitory Antibodies User Guide (602 KB)
References	[1]. D'Souza A, et al. A Phase I First-in-Human Study of ABBV-383, a B-Cell Maturation Antigen × CD3 Bispecific T-Cell Redirecting Antibody, in Patients With Relapsed/Refractory Multiple Myeloma. J Clin Oncol. 2022 Nov 1;40(31):3576-3586. [Content Brief]

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Keywords:

Etentamig2490552-52-6ABBV-383 TNB 383BABBV383ABBV 383CD3Cluster of differentiation 3CancerImmunoglobulin light chain amyloidosisCardiovascular diseasesInhibitorinhibitorinhibit

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Etentamig (Synonyms: ABBV-383; TNB 383B)

Etentamig Featured Recommendations:

Featured Recommendations

•Related Screening Libraries:

Biological Activity

Purity & Documentation

References

Customer Review

Etentamig Related Classifications

Molarity Calculator

Dilution Calculator