Etentamig (Synonyms: ABBV-383; TNB 383B)

Cat. No.: HY-P990785 Purity: 99%: FAQs
Data Sheet SDS COA

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Etentamig is a BCMA × CD3 bispecific T-cell engager (BiTE) that can inhibit the activity of B-cell maturation antigen (BCMA) and activate the T-cell surface glycoprotein CD3 complex. Etentamig can be used for research in multiple myeloma, immunoglobulin light chain amyloidosis, and cardiovascular diseases.

For research use only. We do not sell to patients.

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This product is a controlled substance and not for sale in your territory.

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Description	Etentamig is a BCMA × CD3 bispecific T-cell engager (BiTE) that can inhibit the activity of B-cell maturation antigen (BCMA) and activate the T-cell surface glycoprotein CD3 complex. Etentamig can be used for research in multiple myeloma, immunoglobulin light chain amyloidosis, and cardiovascular diseases^[1].
Isotype	Human IgG4 kappa
Recommend Isotype Controls	Human IgG4 (S228P) kappa, Isotype Control
Appearance	Liquid
Color	Colorless to light yellow
SMILES	[Etentamig]
Shipping	Shipping with dry ice.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity	Loaded ABBV-383 on AHC2 biosensor, can bind BCMA/TNFRSF17 Protein, Human (HEK293, His, HY-P72847) with an affinity constant of 1.731E-11 M as determined in BLI assay. Loaded ABBV-383 on AHC2 biosensor, can bind CD3D-CD3E Heterodimer Protein, Human (HEK293, Fc-Flag&Fc-His, HY-P70434) with an affinity constant of 3.674E-07 M as determined in BLI assay.
Purity & Documentation	Purity: 99% Select Batch: Data Sheet (255 KB) SDS (251 KB) COA (232 KB) Inhibitory Antibodies User Guide (602 KB)
References	[1]. D'Souza A, et al. A Phase I First-in-Human Study of ABBV-383, a B-Cell Maturation Antigen × CD3 Bispecific T-Cell Redirecting Antibody, in Patients With Relapsed/Refractory Multiple Myeloma. J Clin Oncol. 2022 Nov 1;40(31):3576-3586. [Content Brief]

Etentamig Related Classifications

Inhibitory Antibodies

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EtentamigABBV-383 TNB 383BABBV383ABBV 383CD3Cluster of differentiation 3CancerImmunoglobulin light chain amyloidosisCardiovascular diseasesInhibitorinhibitorinhibit

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Etentamig (Synonyms: ABBV-383; TNB 383B)

Etentamig Related Antibodies

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