ABT-418 hydrochloride

Name: ABT-418 hydrochloride
Brand: MedChemExpress
SKU: HY-105170B
Rating: 4.5 (1 reviews)

Cat. No.: HY-105170B Purity: 99.37%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease.

For research use only. We do not sell to patients.

ABT-418 hydrochloride Chemical Structure

CAS No. : 147388-83-8

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 132	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 132	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 600	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 850	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of ABT-418 hydrochloride:

ABT-418 Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

nAChRs^[1]^[2]

In Vivo

ABT-418 hydrochloride (125.66 μg/kg; i.p.) induces a significant increase in the time spent by the rats in the open arms of the elevated plus maze^[1].
Acute administration of ABT-418 (125.66μg/kg; i.p.) also attenuates the anxiogenic-like effect elicited by withdrawal from chronic (-)-nicotine treatment^[1].
ABT-418 hydrochloride (0.6 mg/kg; i.p.; daily; for two weeks) effectively improves spatial memory in an animal model of ADHD^[2].
ABT-418 hydrochloride significantly enhances the cortical α4 and β2 nAChR subunits and the hippocampal α4 subunit expression^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male SHRs (4–5 weeks old), attention deficit hyperactivity disorder (ADHD) model^[2]
Dosage:	0.6 mg/kg
Administration:	Intraperitoneal injection; once daily; for two weeks
Result:	Effectively improved spatial memory.

Molecular Weight

202.68

Formula

C₉H₁₅ClN₂O

CAS No.

147388-83-8

Appearance

Solid

Color

Light brown to brown

SMILES

CN1[C@H](C2=CC(C)=NO2)CCC1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 11.9 mg/mL (58.71 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.9339 mL	24.6694 mL	49.3389 mL
5 mM	0.9868 mL	4.9339 mL	9.8678 mL
10 mM	0.4934 mL	2.4669 mL	4.9339 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (493.39 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.37%

Select Batch:

Data Sheet (276 KB) SDS (420 KB)

COA (251 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Brioni JD, et al. Anxiolytic-like effects of the novel cholinergic channel activator ABT-418. J Pharmacol Exp Ther. 1994 Oct;271(1):353-61. [Content Brief]

[2]. Guo T, et al. A comparative study of the effects of ABT-418 and methylphenidate on spatial memory in an animal model of ADHD. Neurosci Lett. 2012 Oct 18;528(1):11-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	4.9339 mL	24.6694 mL	49.3389 mL	123.3472 mL
	5 mM	0.9868 mL	4.9339 mL	9.8678 mL	24.6694 mL
	10 mM	0.4934 mL	2.4669 mL	4.9339 mL	12.3347 mL
	15 mM	0.3289 mL	1.6446 mL	3.2893 mL	8.2231 mL
	20 mM	0.2467 mL	1.2335 mL	2.4669 mL	6.1674 mL
	25 mM	0.1974 mL	0.9868 mL	1.9736 mL	4.9339 mL
	30 mM	0.1645 mL	0.8223 mL	1.6446 mL	4.1116 mL
	40 mM	0.1233 mL	0.6167 mL	1.2335 mL	3.0837 mL
	50 mM	0.0987 mL	0.4934 mL	0.9868 mL	2.4669 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.