2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. ACG548B

ACG548B (compound 24) is a potent inhibitor of acetyl- and butyrylcholinesterase (AChE and BChE) with IC50s of 1.78 and 0.496 μM, respectively. ACG548B has higher AChE affinity and selectivity over BChE and ChoK (choline kinase).

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ACG548B Chemical Structure

ACG548B Chemical Structure

CAS No. : 795316-16-4

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Based on 1 publication(s) in Google Scholar

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Description

ACG548B (compound 24) is a potent inhibitor of acetyl- and butyrylcholinesterase (AChE and BChE) with IC50s of 1.78 and 0.496 μM, respectively. ACG548B has higher AChE affinity and selectivity over BChE and ChoK (choline kinase)[1].

IC50 & Target

BChE; ChoK[1]
Cellular Effect
Cell Line Type Value Description References
HT-29 IC50
1.9 μM
Compound: 19
Antiproliferative activity was determined using HT-29 human colon cancer cell line
Antiproliferative activity was determined using HT-29 human colon cancer cell line
[PMID: 15481981]
Molecular Weight

777.42

Formula

C38H34Br2Cl2N4
CAS No.
Appearance

Solid

Color

Yellow to brown

SMILES

CN(C1=CC=[N+](CC2=CC(C3=CC=CC(C[N+]4=CC=C(N(C5=CC=C(Cl)C=C5)C)C=C4)=C3)=CC=C2)C=C1)C6=CC=C(Cl)C=C6.[Br-].[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 7.8 mg/mL (10.03 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2863 mL 6.4315 mL 12.8631 mL
5 mM 0.2573 mL 1.2863 mL 2.5726 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2863 mL 6.4315 mL 12.8631 mL 32.1577 mL
5 mM 0.2573 mL 1.2863 mL 2.5726 mL 6.4315 mL
10 mM 0.1286 mL 0.6432 mL 1.2863 mL 3.2158 mL
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ACG548B Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ACG548B795316-16-4Cholinesterase (ChE)AChEBChEChoKaffinityselectivitymyasthenia gravisneuromuscular blockadeInhibitorinhibitorinhibit

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