2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. AChE/BuChE-IN-4

AChE/BuChE-IN-4(compound 4a) is aorally activeandbrain-penetrantmultitarget-directedAChE/BuChEinhibitor againstAChEandBuChE, with theIC50of 2.08 and 7.41 μM.

For research use only. We do not sell to patients.

AChE/BuChE-IN-4 Chemical Structure

AChE/BuChE-IN-4 Chemical Structure

CAS No. : 1997158-25-4

Size Price Stock Quantity
5 mg USD 320 In-stock
10 mg USD 480 In-stock
50 mg USD 980 In-stock
100 mg USD 1450 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

AChE/BuChE-IN-4 Related Antibodies

Top Publications Citing Use of Products

View All Cholinesterase (ChE) Isoform Specific Products:

View All Isoforms
AChE BChE

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

AChE/BuChE-IN-4(compound 4a) is aorally activeandbrain-penetrantmultitarget-directedAChE/BuChEinhibitor againstAChEandBuChE, with theIC50of 2.08 and 7.41 μM[1].

IC50 & Target

2.08 and 7.41 μM([1]
Molecular Weight

297.40

Formula

C17H23N5
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

NC1=NC=CC(NCC2CCN(CC2)CC3=CC=CC=C3)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (420.31 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3625 mL 16.8124 mL 33.6247 mL
5 mM 0.6725 mL 3.3625 mL 6.7249 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3625 mL 16.8124 mL 33.6247 mL 84.0619 mL
5 mM 0.6725 mL 3.3625 mL 6.7249 mL 16.8124 mL
10 mM 0.3362 mL 1.6812 mL 3.3625 mL 8.4062 mL
15 mM 0.2242 mL 1.1208 mL 2.2416 mL 5.6041 mL
20 mM 0.1681 mL 0.8406 mL 1.6812 mL 4.2031 mL
25 mM 0.1345 mL 0.6725 mL 1.3450 mL 3.3625 mL
30 mM 0.1121 mL 0.5604 mL 1.1208 mL 2.8021 mL
40 mM 0.0841 mL 0.4203 mL 0.8406 mL 2.1015 mL
50 mM 0.0672 mL 0.3362 mL 0.6725 mL 1.6812 mL
60 mM 0.0560 mL 0.2802 mL 0.5604 mL 1.4010 mL
80 mM 0.0420 mL 0.2102 mL 0.4203 mL 1.0508 mL
100 mM 0.0336 mL 0.1681 mL 0.3362 mL 0.8406 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

AChE/BuChE-IN-4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE/BuChE-IN-41997158-25-4Cholinesterase (ChE)Alzheimer's diseaseacetylcholinesterasebutyrylcholinesterasein silico toxicitymolecular dynamicsmultitarget ligandsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
AChE/BuChE-IN-4
Cat. No.:
HY-155349
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.