2. Anti-infection
  3. HBV Reverse Transcriptase
  4. Adefovir

Adefovir  (Synonyms: GS-0393; PMEA)

Cat. No.: HY-B1826 Purity: 99.55%
COA Handling Instructions

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Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses.

For research use only. We do not sell to patients.

Adefovir Chemical Structure

Adefovir Chemical Structure

CAS No. : 106941-25-7

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50 mg USD 80 In-stock
100 mg USD 120 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Adefovir:

Adefovir Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Adefovir

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses[1][2][3].

IC50 & Target

HBV[1][2][3];
DNA polymerase[1][2]
In Vitro

Studies to elucidate the mechanism of action of Adefovir against herpesvirus replication reveals that the phosphorylation of Adefovir occurred intracellularly and is carried out by host cellular enzymes. The diphosphorylated derivatives of Adefovir targeted the viral DNA polymerase and also acted as DNA chain terminators. Adenylate kinase is shown to be responsible for the first phosphorylation, which was followed by ADP kinase and creatine kinase, forming Adefovir diphosphate[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Adefovir Related Antibodies
In Vivo

Unaffected by food, Adefovir achieves 60% oral bioavailability. Its half-life is 12-30 hours and Adefovir undergoes renal excretion without significant metabolites. Adefovir does not substantially affect the cytochrome P450 system[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

273.19

Formula

C8H12N5O4P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=C2N=CN(CCOCP(O)(O)=O)C2=NC=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

0.1 M NaOH : 10 mg/mL (36.60 mM; ultrasonic and adjust pH to 10 with NaOH)

H2O : < 0.1 mg/mL (insoluble)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6605 mL 18.3023 mL 36.6046 mL
5 mM 0.7321 mL 3.6605 mL 7.3209 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.74%

COA (246 KB) HNMR (117 KB) RP-HPLC (191 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
0.1 M NaOH 1 mM 3.6605 mL 18.3023 mL 36.6046 mL 91.5114 mL
5 mM 0.7321 mL 3.6605 mL 7.3209 mL 18.3023 mL
10 mM 0.3660 mL 1.8302 mL 3.6605 mL 9.1511 mL
15 mM 0.2440 mL 1.2202 mL 2.4403 mL 6.1008 mL
20 mM 0.1830 mL 0.9151 mL 1.8302 mL 4.5756 mL
25 mM 0.1464 mL 0.7321 mL 1.4642 mL 3.6605 mL
30 mM 0.1220 mL 0.6101 mL 1.2202 mL 3.0504 mL
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Adefovir Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Adefovir106941-25-7GS-0393 PMEAGS0393GS 0393HBVReverse TranscriptaseHepatitis B virusreversetranscriptaseantiviraldiphosphateadenosinemonophosphateHIVherpesvirusesInhibitorinhibitorinhibit

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