C-33-A
|
IC50 |
|
Antiproliferative activity against human C33A cells after 72 hrs by flow cytometric analysis
Antiproliferative activity against human C33A cells after 72 hrs by flow cytometric analysis
|
[PMID: 24686012]
|
C3H/3T3
|
EC50 |
0.53 μM
Compound: PMEA, Adefovir
|
Inhibition of murine sarcoma virus-induced transformation of mouse embryo fibroblast C3H/3T3 cells after 6 days
Inhibition of murine sarcoma virus-induced transformation of mouse embryo fibroblast C3H/3T3 cells after 6 days
|
[PMID: 18556209]
|
C3H/3T3
|
EC50 |
|
Antiviral against Moloney murine sarcoma virus infected in mouse C3H/3T3 cells assessed as inhibition of virus-induced cell transformation after 6 days post infection by microscopic analysis
Antiviral against Moloney murine sarcoma virus infected in mouse C3H/3T3 cells assessed as inhibition of virus-induced cell transformation after 6 days post infection by microscopic analysis
|
[PMID: 21429755]
|
C8166
|
EC50 |
|
Concentration required to inhibit p24 viral antigen production by 50% in C-8166 cells
Concentration required to inhibit p24 viral antigen production by 50% in C-8166 cells
|
10.1016/0960-894X(95)00208-B
|
C8166
|
EC50 |
7 μM
Compound: PMEA, Adefovir
|
Antiviral activity against 100 TCID50 wild-type Human immunodeficiency virus type 2 ROD infected in C8166 cells assessed as inhibition of syncytia formation after 4 days by microscopic analysis
Antiviral activity against 100 TCID50 wild-type Human immunodeficiency virus type 2 ROD infected in C8166 cells assessed as inhibition of syncytia formation after 4 days by microscopic analysis
|
[PMID: 21803462]
|
CCRF-CEM
|
CC50 |
|
Cytotoxicity against human CEM cells assessed as inhibition of cell proliferation after 72 hrs by coulter counter analysis
Cytotoxicity against human CEM cells assessed as inhibition of cell proliferation after 72 hrs by coulter counter analysis
|
[PMID: 21429755]
|
CCRF-CEM
|
EC50 |
10.4 μM
Compound: 1, PMEA, Adefovir
|
Antiviral activity against HIV 1 3B infected in CEM cells assessed as inhibition of virus-induced giant cell formation after 4 days by microscopy
Antiviral activity against HIV 1 3B infected in CEM cells assessed as inhibition of virus-induced giant cell formation after 4 days by microscopy
|
[PMID: 21565516]
|
CCRF-CEM
|
CC50 |
164 μM
Compound: 1, PMEA, Adefovir
|
Cytotoxicity against human CEM cells assessed as growth inhibition after 3 days by coulter counting analysis
Cytotoxicity against human CEM cells assessed as growth inhibition after 3 days by coulter counting analysis
|
[PMID: 21565516]
|
CCRF-CEM
|
EC50 |
|
In vitro anti -HIV activity tested against CEM cells infected with HIV by XTT assay
In vitro anti -HIV activity tested against CEM cells infected with HIV by XTT assay
|
[PMID: 1323678]
|
CCRF-CEM
|
IC50 |
|
Cytostatic activity against human CEM cells after 72 hrs by coulter counting analysis
Cytostatic activity against human CEM cells after 72 hrs by coulter counting analysis
|
[PMID: 24686012]
|
CCRF-CEM
|
EC50 |
5.5 μM
Compound: PMEA, Adefovir
|
Antiviral activity against 100 TCID50 wild-type Human immunodeficiency virus 1 3B infected in CEM cells assessed as inhibition of syncytia formation after 4 days by microscopic analysis
Antiviral activity against 100 TCID50 wild-type Human immunodeficiency virus 1 3B infected in CEM cells assessed as inhibition of syncytia formation after 4 days by microscopic analysis
|
[PMID: 21803462]
|
CCRF-CEM
|
EC50 |
7 μM
Compound: PMEA, adefovir
|
Antiviral activity against Human immunodeficiency virus type 2 ROD infected in human CEM cells assessed as HIV-induced CEM giant cell formation after 4 days by microscopy
Antiviral activity against Human immunodeficiency virus type 2 ROD infected in human CEM cells assessed as HIV-induced CEM giant cell formation after 4 days by microscopy
|
[PMID: 21745746]
|
CCRF-CEM
|
EC50 |
|
Antiviral activity against HIV2 ROD infected in human CEM cells assessed as inhibition of virus-induced syncytium formation after 4 to 5 days by microscopic analysis
Antiviral activity against HIV2 ROD infected in human CEM cells assessed as inhibition of virus-induced syncytium formation after 4 to 5 days by microscopic analysis
|
[PMID: 21429755]
|
CCRF-CEM
|
EC50 |
7.4 μM
Compound: PMEA, adefovir
|
Antiviral activity against Human immunodeficiency virus type1 3B infected in human CEM cells assessed as HIV-induced CEM giant cell formation after 4 days by microscopic analysis
Antiviral activity against Human immunodeficiency virus type1 3B infected in human CEM cells assessed as HIV-induced CEM giant cell formation after 4 days by microscopic analysis
|
[PMID: 21745746]
|
CCRF-CEM
|
EC50 |
|
Antiviral activity against HIV1 3B infected in human CEM cells assessed as inhibition of virus-induced syncytium formation after 4 to 5 days by microscopic analysis
Antiviral activity against HIV1 3B infected in human CEM cells assessed as inhibition of virus-induced syncytium formation after 4 to 5 days by microscopic analysis
|
[PMID: 21429755]
|
CCRF-CEM
|
EC50 |
|
Antiviral activity against Human immunodeficiency virus type 2 ROD infected in human CEM cells assessed as inhibition of virus-induced giant cell formation after 4 to 5 days by microscopic analysis
Antiviral activity against Human immunodeficiency virus type 2 ROD infected in human CEM cells assessed as inhibition of virus-induced giant cell formation after 4 to 5 days by microscopic analysis
|
[PMID: 24686012]
|
CCRF-CEM
|
EC50 |
|
Antiviral activity against Human immunodeficiency virus 1 3B infected in human CEM cells assessed as inhibition of virus-induced giant cell formation after 4 to 5 days by microscopic analysis
Antiviral activity against Human immunodeficiency virus 1 3B infected in human CEM cells assessed as inhibition of virus-induced giant cell formation after 4 to 5 days by microscopic analysis
|
[PMID: 24686012]
|
CCRF-CEM
|
EC50 |
8.6 μM
Compound: 1, PMEA, Adefovir
|
Antiviral activity against HIV 2 ROD infected in CEM cells assessed as inhibition of virus-induced giant cell formation after 4 days by microscopy
Antiviral activity against HIV 2 ROD infected in CEM cells assessed as inhibition of virus-induced giant cell formation after 4 days by microscopy
|
[PMID: 21565516]
|
CHO
|
CC50 |
≥ 2000 μM
Compound: Adefovir
|
Cytotoxicity against CHO cells after 120 hrs by Cell-Titer Glo assay
Cytotoxicity against CHO cells after 120 hrs by Cell-Titer Glo assay
|
[PMID: 19001108]
|
CHO
|
CC50 |
1.4 μM
Compound: Adefovir
|
Ratio of CC50 for CHO cells to CC50 for CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay
Ratio of CC50 for CHO cells to CC50 for CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay
|
[PMID: 19001108]
|
CHO
|
CC50 |
|
Cytotoxicity against CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay
Cytotoxicity against CHO cells expressing hOAT1 after 120 hrs by Cell-Titer Glo assay
|
[PMID: 19001108]
|
H9
|
CC50 |
> 30 μM
Compound: PMEA, Adefovir
|
Cytotoxicity against PAP-activated human H9 cells on day 7 by MTT assay
Cytotoxicity against PAP-activated human H9 cells on day 7 by MTT assay
|
[PMID: 21803462]
|
H9
|
EC50 |
1.1 μM
Compound: PMEA, Adefovir
|
Antiviral activity against 125 TCID50 wild type HIV1 LAI infected in human H9 cells assessed as reduction in viral replication measured on day 7 post infection by reverse transcriptase activity
Antiviral activity against 125 TCID50 wild type HIV1 LAI infected in human H9 cells assessed as reduction in viral replication measured on day 7 post infection by reverse transcriptase activity
|
[PMID: 21803462]
|
H9
|
EC50 |
7.9 μM
Compound: PMEA, Adefovir
|
Antiviral activity against 6250 TCID50 wild type HIV1 LAI infected in human H9 cells assessed as reduction in viral replication measured on day 7 post infection by reverse transcriptase activity
Antiviral activity against 6250 TCID50 wild type HIV1 LAI infected in human H9 cells assessed as reduction in viral replication measured on day 7 post infection by reverse transcriptase activity
|
[PMID: 21803462]
|
HEK-293T
|
CC50 |
|
Cytotoxicity against human 293T cells assessed as inhibition of cell proliferation by tetrazolium dye method
Cytotoxicity against human 293T cells assessed as inhibition of cell proliferation by tetrazolium dye method
|
[PMID: 17470654]
|
HEL 299
|
EC50 |
> 183 μM
Compound: 3a, PMEA
|
Antiviral activity against Camelpox virus CML1 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining
Antiviral activity against Camelpox virus CML1 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining
|
[PMID: 17893157]
|
HEL 299
|
EC50 |
> 183 μM
Compound: 3a, PMEA
|
Antiviral activity against Camelpox virus CML14 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining
Antiviral activity against Camelpox virus CML14 infected in HEL299 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by Giemsa staining
|
[PMID: 17893157]
|
HEL 299
|
CC50 |
211 μM
Compound: 3a, PMEA
|
Cytotoxicity against HEL299 cells after 4 days by Z1 Coulter counting analysis
Cytotoxicity against HEL299 cells after 4 days by Z1 Coulter counting analysis
|
[PMID: 17893157]
|
HeLa
|
CC50 |
> 250 μM
Compound: 1, PMEA, Adefovir
|
Cytotoxicity against human HeLa cells assessed as growth inhibition after 3 days by coulter counting analysis
Cytotoxicity against human HeLa cells assessed as growth inhibition after 3 days by coulter counting analysis
|
[PMID: 21565516]
|
HeLa
|
IC50 |
|
Cytostatic activity against human HeLa cells after 72 hrs by coulter counting analysis
Cytostatic activity against human HeLa cells after 72 hrs by coulter counting analysis
|
[PMID: 24686012]
|
HepG2
|
IC50 |
42.1 μM
Compound: PMEA, 1
|
Antiviral activity against Hepatitis B virus infected human HepG2 cells after 9 days by MTT assay
Antiviral activity against Hepatitis B virus infected human HepG2 cells after 9 days by MTT assay
|
[PMID: 17888662]
|
HepG2 2.2.15
|
IC50 |
0.517 μM
Compound: adefovir
|
Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBV DNA replication after 9 days by PCR
Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBV DNA replication after 9 days by PCR
|
[PMID: 20000776]
|
HepG2 2.2.15
|
IC50 |
0.517 μM
Compound: Adefovir
|
Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of viral replication after 9 days by fluorescence PCR method
Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of viral replication after 9 days by fluorescence PCR method
|
[PMID: 23353737]
|
HepG2 2.2.15
|
EC50 |
1.3 μM
Compound: Adefovir
|
Antiviral activity against wild type Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization method
Antiviral activity against wild type Hepatitis B virus infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization method
|
[PMID: 21930377]
|
HepG2 2.2.15
|
EC50 |
1.6 μM
Compound: Adefovir
|
Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase M204V mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization me
Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase M204V mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization me
|
[PMID: 21930377]
|
HepG2 2.2.15
|
EC50 |
1.9 μM
Compound: Adefovir
|
Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase M204I mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization me
Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase M204I mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization me
|
[PMID: 21930377]
|
HepG2 2.2.15
|
EC50 |
2.1 μM
Compound: Adefovir
|
Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase L180M/M204V double mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hyb
Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase L180M/M204V double mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hyb
|
[PMID: 21930377]
|
HepG2 2.2.15
|
CC50 |
200 μM
Compound: Adefovir
|
Cytotoxicity in human HepG2.215 cells assessed as reduction in cell viability after 5 days by CCK8 assay
Cytotoxicity in human HepG2.215 cells assessed as reduction in cell viability after 5 days by CCK8 assay
|
[PMID: 28082068]
|
HepG2 2.2.15
|
IC50 |
215 μM
Compound: Adefovir
|
Antiviral activity against hepatitis B viral in human HepG2.2.15 cells assessed as HBeAg secretion after 9 days by ELISA
Antiviral activity against hepatitis B viral in human HepG2.2.15 cells assessed as HBeAg secretion after 9 days by ELISA
|
[PMID: 25650312]
|
HepG2 2.2.15
|
IC50 |
257 μM
Compound: Adefovir
|
Antiviral activity against hepatitis B viral in human HepG2.2.15 cells assessed as surface antigen HBsAg secretion after 9 days by ELISA
Antiviral activity against hepatitis B viral in human HepG2.2.15 cells assessed as surface antigen HBsAg secretion after 9 days by ELISA
|
[PMID: 25650312]
|
HepG2 2.2.15
|
IC50 |
286 μM
Compound: Adefovir
|
Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBeAg production after 9 days by ELISA
Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBeAg production after 9 days by ELISA
|
[PMID: 23353737]
|
HepG2 2.2.15
|
IC50 |
286 μM
Compound: adefovir
|
Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBeAg level after 9 days by ELISA
Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBeAg level after 9 days by ELISA
|
[PMID: 20000776]
|
HepG2 2.2.15
|
IC50 |
305 μM
Compound: Adefovir
|
Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBsAg production after 9 days by ELISA
Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBsAg production after 9 days by ELISA
|
[PMID: 23353737]
|
HepG2 2.2.15
|
IC50 |
305 μM
Compound: adefovir
|
Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBsAg level after 9 days by ELISA
Antiviral activity against HBV infected in human HepG2(2.2.15) cells assessed as inhibition of HBsAg level after 9 days by ELISA
|
[PMID: 20000776]
|
HepG2 2.2.15
|
CC50 |
490 μM
Compound: Adefovir
|
Cytotoxicity against human HepG2.2.15 cells assessed as cell death after 9 days by MTS assay
Cytotoxicity against human HepG2.2.15 cells assessed as cell death after 9 days by MTS assay
|
[PMID: 25650312]
|
HepG2 2.2.15
|
EC50 |
5.5 μM
Compound: Adefovir
|
Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase L180M mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization me
Antiviral activity against lamivudine-resistant Hepatitis B virus harboring reverse transcriptase L180M mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization me
|
[PMID: 21930377]
|
HepG2 2.2.15
|
CC50 |
540 μM
Compound: Adefovir
|
Cytotoxicity against human HepG2(2.2.15) cells compound treated for 48 hrs followed by incubation for 9 days by MTT assay
Cytotoxicity against human HepG2(2.2.15) cells compound treated for 48 hrs followed by incubation for 9 days by MTT assay
|
[PMID: 23353737]
|
HepG2 2.2.15
|
CC50 |
|
Cytotoxicity against HepG2.2.15 cells after 6 hrs by MTT assay
Cytotoxicity against HepG2.2.15 cells after 6 hrs by MTT assay
|
[PMID: 17499889]
|
HepG2 2.2.15
|
EC50 |
7.8 μM
Compound: Adefovir
|
Antiviral activity against adefovir-resistant Hepatitis B virus harboring reverse transcriptase N236T mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization meth
Antiviral activity against adefovir-resistant Hepatitis B virus harboring reverse transcriptase N236T mutant infected in human HepG2(2.2.15) cells assessed as inhibition of virus replication treated daily for 9 days by quantitative blot hybridization meth
|
[PMID: 21930377]
|
Huh-7
|
EC50 |
1.3 μM
Compound: adefovir
|
Antiviral activity against adefovir-resistant wild type HBV in human Huh7 cells after 4 days by intracellular HBV DNA replication assay
Antiviral activity against adefovir-resistant wild type HBV in human Huh7 cells after 4 days by intracellular HBV DNA replication assay
|
[PMID: 19072694]
|
Huh-7
|
EC50 |
1.5 μM
Compound: adefovir
|
Antiviral activity against adefovir-resistant HBV reverse transcriptase M204V mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay
Antiviral activity against adefovir-resistant HBV reverse transcriptase M204V mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay
|
[PMID: 19072694]
|
Huh-7
|
EC50 |
1.6 μM
Compound: adefovir
|
Antiviral activity against adefovir-resistant HBV reverse transcriptase L180M mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay
Antiviral activity against adefovir-resistant HBV reverse transcriptase L180M mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay
|
[PMID: 19072694]
|
Huh-7
|
EC50 |
1.6 μM
Compound: adefovir
|
Antiviral activity against adefovir-resistant HBV reverse transcriptase LM/reverse transcriptase MV double mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay
Antiviral activity against adefovir-resistant HBV reverse transcriptase LM/reverse transcriptase MV double mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay
|
[PMID: 19072694]
|
Huh-7
|
EC50 |
1.8 μM
Compound: adefovir
|
Antiviral activity against adefovir-resistant HBV reverse transcriptase M204I mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay
Antiviral activity against adefovir-resistant HBV reverse transcriptase M204I mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay
|
[PMID: 19072694]
|
Huh-7
|
EC50 |
6 μM
Compound: PMEA, Adefovir
|
Antiviral activity against Hepatitis B virus infected in human HuH7 cells assessed as reduction in viral DNA level treated day 3 to day 8 post transfection by real time quantitative PCR analysis
Antiviral activity against Hepatitis B virus infected in human HuH7 cells assessed as reduction in viral DNA level treated day 3 to day 8 post transfection by real time quantitative PCR analysis
|
[PMID: 21803462]
|
Huh-7
|
EC50 |
7.7 μM
Compound: adefovir
|
Antiviral activity against adefovir-resistant HBV reverse transcriptase 236T mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay
Antiviral activity against adefovir-resistant HBV reverse transcriptase 236T mutant in human Huh7 cells after 4 days by intracellular HBV DNA replication assay
|
[PMID: 19072694]
|
L1210
|
IC50 |
|
Cytostatic activity against mouse L1210 cells after 48 hrs by coulter counting analysis
Cytostatic activity against mouse L1210 cells after 48 hrs by coulter counting analysis
|
[PMID: 24686012]
|
MT4
|
EC50 |
|
Concentration required to inhibit HIV-1-induced cytopathic effect by 50% in MT-4 cells
Concentration required to inhibit HIV-1-induced cytopathic effect by 50% in MT-4 cells
|
10.1016/0960-894X(95)00208-B
|
PBMC
|
CC50 |
> 30 μM
Compound: PMEA, Adefovir
|
Cytotoxicity against PAP-activated human PBMC on day 7 by MTT assay
Cytotoxicity against PAP-activated human PBMC on day 7 by MTT assay
|
[PMID: 21803462]
|
Vero
|
IC50 |
|
Concentration that reduced plaque formation by 50% was measured in HSV-2 infected vero cells in vitro
Concentration that reduced plaque formation by 50% was measured in HSV-2 infected vero cells in vitro
|
[PMID: 8021925]
|
WI-38
|
CC50 |
|
Cytotoxicity against human WI38 cells by neutral red assay
Cytotoxicity against human WI38 cells by neutral red assay
|
[PMID: 18285481]
|
WI-38
|
EC50 |
|
Antimicrobial activity against BK polyomavirus ATCC VR837 infected in human WI38 cells assessed as reduction in viral titer after 7 days by PCR analysis
Antimicrobial activity against BK polyomavirus ATCC VR837 infected in human WI38 cells assessed as reduction in viral titer after 7 days by PCR analysis
|
[PMID: 18285481]
|