2. Immunology/Inflammation
  3. Aryl Hydrocarbon Receptor
  4. AhR agonist 2

AhR agonist 2 (Compound 12a) is a potent agonist of aryl hydrocarbon receptor (AhR) with an EC50 of 0.03 nM. AhR agonist 2 induces rapid nuclear enrichment of AhR, triggers the transcription of downstream genes and promote skin barrier repair. AhR agonist 2 has the potential for the research of psoriasis.

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AhR agonist 2 Chemical Structure

AhR agonist 2 Chemical Structure

CAS No. : 2975270-19-8

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Based on 1 publication(s) in Google Scholar

AhR agonist 2 Related Antibodies

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Description

AhR agonist 2 (Compound 12a) is a potent agonist of aryl hydrocarbon receptor (AhR) with an EC50 of 0.03 nM. AhR agonist 2 induces rapid nuclear enrichment of AhR, triggers the transcription of downstream genes and promote skin barrier repair. AhR agonist 2 has the potential for the research of psoriasis[1].

Cellular Effect
Cell Line Type Value Description References
BEAS-2B IC50
> 300 μM
Compound: 12a
Cytotoxicity against human BEAS-2B cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human BEAS-2B cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 35123295]
HEK-293T IC50
> 300 μM
Compound: 12a
Cytotoxicity against HEK293T cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against HEK293T cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 35123295]
HUVEC IC50
> 300 μM
Compound: 12a
Cytotoxicity against human HUVEC cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human HUVEC cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 35123295]
LX-2 IC50
> 300 μM
Compound: 12a
Cytotoxicity against human LX2 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
Cytotoxicity against human LX2 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
[PMID: 35123295]
Molecular Weight

353.01

Formula

C12H7Br2N3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

BrC1=CC=C(C=C1)C2=NN3C=C(C=CC3=N2)Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (59.01 mM; ultrasonic and warming and heat to 70°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8328 mL 14.1639 mL 28.3278 mL
5 mM 0.5666 mL 2.8328 mL 5.6656 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8328 mL 14.1639 mL 28.3278 mL 70.8195 mL
5 mM 0.5666 mL 2.8328 mL 5.6656 mL 14.1639 mL
10 mM 0.2833 mL 1.4164 mL 2.8328 mL 7.0820 mL
15 mM 0.1889 mL 0.9443 mL 1.8885 mL 4.7213 mL
20 mM 0.1416 mL 0.7082 mL 1.4164 mL 3.5410 mL
25 mM 0.1133 mL 0.5666 mL 1.1331 mL 2.8328 mL
30 mM 0.0944 mL 0.4721 mL 0.9443 mL 2.3607 mL
40 mM 0.0708 mL 0.3541 mL 0.7082 mL 1.7705 mL
50 mM 0.0567 mL 0.2833 mL 0.5666 mL 1.4164 mL
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AhR agonist 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AhR agonist 22975270-19-8AhR agonist2AhR agonist-2Aryl Hydrocarbon ReceptorAhRtranscriptionskin barrier repairpsoriasisInhibitorinhibitorinhibit

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