[Ala1,3,11,15]-Endothelin (53-63)

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[Ala1,3,11,15]-Endothelin (53-63) is an ET_B agonist. [Ala1,3,11,15]-Endothelin (53-63) has selectivity for ET^B with IC₅₀ values range from 0.33 nM to 0.61 nM. [Ala1,3,11,15]-Endothelin (53-63) can be used for the research of vasoconstriction

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[Ala1,3,11,15]-Endothelin (53-63) Chemical Structure

CAS No. : 121204-87-3

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Other Forms of [Ala1,3,11,15]-Endothelin (53-63):

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ET_A ET_B

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Description	[Ala1,3,11,15]-Endothelin (53-63) is an ET_B agonist. [Ala1,3,11,15]-Endothelin (53-63) has selectivity for ET^B with IC₅₀ values range from 0.33 nM to 0.61 nM. [Ala1,3,11,15]-Endothelin (53-63) can be used for the research of vasoconstriction^[1]
IC₅₀ & Target	IC50 for ET^B: 0.61 nM (Bronchus); 0.61 nM (Lung); 0.33 nM (Cerebellum); 2200 nM (VSMC)^[1]
In Vitro	[Ala1,3,11,15]-Endothelin (53-63) (0.1 μM) has selectivity for ET^B with IC₅₀ values of 0.61 nM, 0.61 nM, 0.33 nM, 2200 nM in Bronchus, Lung, Cerebellum and VSMC, respectively^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. [Ala1,3,11,15]-Endothelin (53-63) Related Antibodies
Molecular Weight	2367.67
Formula	C₁₀₉H₁₆₃N₂₅O₃₂S
CAS No.	121204-87-3
Sequence Shortening	ASASSLMDKEAVYFAHLDIIW
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (258 KB) Handling Instructions (2659 KB)
References	[1]. Nakamichi K, et al. Different distribution of endothelin receptor subtypes in pulmonary tissues revealed by the novel selective ligands BQ-123 and [Ala1,3,11,15]ET-1. Biochem Biophys Res Commun. 1992 Jan 15;182(1):144-50. [Content Brief]