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  4. Therapeutic Peptides
  5. Alirinetide

Alirinetide (GM604) is an oligopeptide containing 6 amino acids. Alirinetide can cross the blood-brain barrier and can be used for the research of multiple neurodegenerative diseases.

For research use only. We do not sell to patients.

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Alirinetide Chemical Structure

Alirinetide Chemical Structure

CAS No. : 725715-18-4

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Based on 1 publication(s) in Google Scholar

Alirinetide Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Alirinetide (GM604) is an oligopeptide containing 6 amino acids. Alirinetide can cross the blood-brain barrier and can be used for the research of multiple neurodegenerative diseases[1].

In Vitro

Alirinetide (GM604) (0.1-10 mg/mL; 24 h) prevents SH-SY5Y cell death[1].
Alirinetide (48 h) predominantly represses Parkinson’s disease-associated genes in SH-SY5Y cells, these genes were largely associated with the mitochondrial protein complex and respiratory chain[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Alirinetide Related Antibodies

Cell Viability Assay[1]

Cell Line: SH-SY5Y cells
Concentration: 0.1, 1 or 10 mg/mL
Incubation Time: 24 h
Result: Led to dose-dependent rescue of cell survival, with complete recovery of cell viability at the highest dose (10 mg/mL).
In Vivo

Alirinetide (GM604) (0-20 mg/kg; i.v.; twice daily for 5 days) improves behavioral, biochemical, and histological features in the 6-OHDA mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice, 6-hydroxydopamine (6-OHDA) mouse model[1]
Dosage: 0, 1, 5, 10 or 20 mg/kg
Administration: Intravenous injection, twice daily for 5 days
Result: Almost completely abrogated 6-OHDA effects at the highest dose, leading to improved motor performance, increased numbers of TH-positive neurons in the substantia nigra, and increased brain levels of dopamine, 3,4-Dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA).
Clinical Trial
Molecular Weight

798.89

Formula

C36H54N12O9
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (125.17 mM; Need ultrasonic)

DMSO : 100 mg/mL (125.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2517 mL 6.2587 mL 12.5174 mL
5 mM 0.2503 mL 1.2517 mL 2.5035 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.73%

COA (247 KB) RP-HPLC (108 KB) MS (189 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.2517 mL 6.2587 mL 12.5174 mL 31.2934 mL
5 mM 0.2503 mL 1.2517 mL 2.5035 mL 6.2587 mL
10 mM 0.1252 mL 0.6259 mL 1.2517 mL 3.1293 mL
15 mM 0.0834 mL 0.4172 mL 0.8345 mL 2.0862 mL
20 mM 0.0626 mL 0.3129 mL 0.6259 mL 1.5647 mL
25 mM 0.0501 mL 0.2503 mL 0.5007 mL 1.2517 mL
30 mM 0.0417 mL 0.2086 mL 0.4172 mL 1.0431 mL
40 mM 0.0313 mL 0.1565 mL 0.3129 mL 0.7823 mL
50 mM 0.0250 mL 0.1252 mL 0.2503 mL 0.6259 mL
60 mM 0.0209 mL 0.1043 mL 0.2086 mL 0.5216 mL
80 mM 0.0156 mL 0.0782 mL 0.1565 mL 0.3912 mL
100 mM 0.0125 mL 0.0626 mL 0.1252 mL 0.3129 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Alirinetide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alirinetide725715-18-4GM604GM 604GM-604OthersParkinson’s diseaseblood-brain barrierneurodegenerative diseasesamyotrophic lateral sclerosisALSInhibitorinhibitorinhibit

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