2. Metabolic Enzyme/Protease
  3. Proteasome Cathepsin
  4. ALLM

ALLM  (Synonyms: Calpain inhibitor II)

Cat. No.: HY-118355 Purity: ≥98.0%
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ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI).

For research use only. We do not sell to patients.

ALLM Chemical Structure

ALLM Chemical Structure

CAS No. : 110115-07-6

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1 mg USD 60 In-stock
5 mg USD 185 In-stock
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Based on 1 publication(s) in Google Scholar

ALLM Related Antibodies

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Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

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Description

ALLM (Calpain inhibitor II) is a potent inhibitor of calpain and cathepsin proteases. ALLM inhibits neuronal cell death and improves chronic neurological function after spinal cord injury (SCI)[1][2].

Cellular Effect
Cell Line Type Value Description References
A549 CC50
> 100 μM
Compound: 119
Cytotoxicity against human A549 cells assessed as reduction in cell viability by neutral red uptake assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability by neutral red uptake assay
[PMID: 34798775]
Caco-2 CC50
> 100 μM
Compound: 119
Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability by neutral red uptake assay
Cytotoxicity against human Caco-2 cells assessed as reduction in cell viability by neutral red uptake assay
[PMID: 34798775]
MDCK CC50
> 100 μM
Compound: 119
Cytotoxicity against dog MDCK cells assessed as reduction in cell viability by neutral red uptake assay
Cytotoxicity against dog MDCK cells assessed as reduction in cell viability by neutral red uptake assay
[PMID: 34798775]
Vero CC50
> 100 μM
Compound: 119
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by neutral red uptake assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by neutral red uptake assay
[PMID: 34798775]
In Vivo

ALLM (Calpain inhibitor II) (0.5 mg/kg) is injected every 24 h for 5 days after SCI and inhibits the activation of calpain but not that of caspase 3. ALLM prevents this neuronal cell death[2].
ALLM (0.05-2.5 mg/kg; i.p.; every 24 h for 1 week) reduces motor disturbances after spinal cord injury (SCI)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Wistar rats (280-300g) (spinal cord injury model)[2]
Dosage: 0.05, 0.5, and 2.5 mg/kg
Administration: Intraperitoneally; every 24 h for 1 week
Result: Showed significantly better motor function.
Molecular Weight

401.56

Formula

C19H35N3O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CSCC[C@@H](C=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(C)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : ≥ 20 mg/mL (49.81 mM)

Ethanol : ≥ 20 mg/mL (49.81 mM)

DMSO : ≥ 20 mg/mL (49.81 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4903 mL 12.4514 mL 24.9029 mL
5 mM 0.4981 mL 2.4903 mL 4.9806 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (251 KB)

COA (246 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF / Ethanol / DMSO 1 mM 2.4903 mL 12.4514 mL 24.9029 mL 62.2572 mL
5 mM 0.4981 mL 2.4903 mL 4.9806 mL 12.4514 mL
10 mM 0.2490 mL 1.2451 mL 2.4903 mL 6.2257 mL
15 mM 0.1660 mL 0.8301 mL 1.6602 mL 4.1505 mL
20 mM 0.1245 mL 0.6226 mL 1.2451 mL 3.1129 mL
25 mM 0.0996 mL 0.4981 mL 0.9961 mL 2.4903 mL
30 mM 0.0830 mL 0.4150 mL 0.8301 mL 2.0752 mL
40 mM 0.0623 mL 0.3113 mL 0.6226 mL 1.5564 mL
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ALLM Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALLM110115-07-6Calpain inhibitor IIProteasomeCathepsinneuronalcellchronicneurologicalfunctionspinalcordinjurymotorInhibitorinhibitorinhibit

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