2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Almonertinib (Standard)

Almonertinib (Standard) 

Cat. No.: HY-112823R Purity: ≥98%
Handling Instructions

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Almonertinib (Standard) is the analytical standard of Almonertinib. This product is intended for research and analytical applications. Almonertinib (HS-10296) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib is used for the research of the non-small cell lung cancer.

For research use only. We do not sell to patients.

Almonertinib (Standard) Chemical Structure

Almonertinib (Standard) Chemical Structure

CAS No. : 1899921-05-1

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100 mg USD 4455 Ask For Quote & Lead Time

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Description
Molecular Weight

525.64

Formula

C30H35N7O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC(C=C(N(C)CCN(C)C)C(NC(C=C)=O)=C1)=C1NC2=NC(C3=CN(C4CC4)C5=C3C=CC=C5)=CC=N2
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Almonertinib (Standard) Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Almonertinib (Standard)1899921-05-1EGFREpidermal growth factor receptorErbB-1HER1oralantineoplasticmutationsG719Xdel19L858RL861Qnon-smallcelllungcancerNSCLCInhibitorinhibitorinhibit

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