α2β1 Integrin Ligand Peptide  (Synonyms: DGEA peptide)

α2β1 Integrin Ligand Peptide interacts with the α2β1 integrin receptor on the cell membrane and mediates extracellular signals into cells. It is a potential antagonist of collagen receptors^[1].

α2β1 Integrin Ligand Peptide (DGEA) (0.015-2.0 mM) inhibits SA11, RRV, and Wa infection in a dose-dependent manner and had no effect on CRW-8 infectivity^[1].
α2β1 Integrin Ligand Peptide induces tyrosine kinase-dependent calcium mobilization in osteoblasts and fibroblasts at concentrations of ≥0.5 mM^[1].
α2β1 Integrin Ligand Peptide loses its ability to inhibit SA11 binding at 1.0 mM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

390.35

C₁₄H₂₂N₄O₉

134580-64-6

Asp-Gly-Glu-Ala

DGEA

C[C@@H](C(O)=O)NC([C@H](CCC(O)=O)NC(CNC([C@H](CC(O)=O)N)=O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Graham KL, et al. Effects on rotavirus cell binding and infection of monomeric and polymeric peptides containing alpha2beta1 and alphaxbeta2 integrin ligand sequences. J Virol. 2004 Nov;78(21):11786-97.  [Content Brief]