2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Anbenitamab

Anbenitamab  (Synonyms: KN-026)

Cat. No.: HY-P99437 Purity: 99.22%
COA

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Anbenitamab (KN-026) is a bispecific antibody simultaneously targeting the extracellular domains II and IV of the human HER2. Anbenitamab blocks both ligand-dependent and ligand-independent HER2 signaling pathway. The IgG1 Fc fragment of Anbenitamab binds FcRγIIIa mediates potent antibody dependent cell-mediated cytotoxicity (ADCC) and inhibits tumor cell proliferation. Anbenitamab has the potential for HER2-positive metastatic breast cancer (MBC) research.

For research use only. We do not sell to patients.

CAS No. : 2367012-88-0

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1 mg USD 450 In-stock
5 mg USD 1170 In-stock
10 mg USD 1870 In-stock
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Based on 1 publication(s) in Google Scholar

Anbenitamab Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Anbenitamab

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Description

Anbenitamab (KN-026) is a bispecific antibody simultaneously targeting the extracellular domains II and IV of the human HER2. Anbenitamab blocks both ligand-dependent and ligand-independent HER2 signaling pathway. The IgG1 Fc fragment of Anbenitamab binds FcRγIIIa mediates potent antibody dependent cell-mediated cytotoxicity (ADCC) and inhibits tumor cell proliferation. Anbenitamab has the potential for HER2-positive metastatic breast cancer (MBC) research[1][2].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Bispecific; Humanized

IC50 & Target[1]

Human HER2

 

Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anbenitamab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Purity & Documentation

Purity: 99.22%

COA (231 KB) MS (588 KB) SDS-PAGE (272 KB) SEC-HPLC (629 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Anbenitamab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anbenitamab2367012-88-0KN-026KN026KN 026EGFREpidermal growth factor receptorErbB-1HER1HER2IgG1Fc fragmentFcRγIIIaantibody dependent cell-mediated cytotoxicityADCCproliferationmetastatic breast cancerMBCInhibitorinhibitorinhibit

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