Anditixafortide

Cat. No.: HY-P2218 Purity: 99.25%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Anditixafortide (Pentixather) is an endoradiotherapeutic vector. Anditixafortide is a CXCR4-targeting peptide derivative. Anditixafortide can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Anditixafortide Chemical Structure

CAS No. : 1821136-83-7

Size	Stock	Quantity
500 μg	In-stock	Estimated Time of Arrival: December 31
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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RDC Peptide RDC Antibody RDC Bifunctional Chelator RDC Linker Other

View All CXCR Isoform Specific Products:

View All Isoforms

CXCR CXCR1 CXCR2 CXCR3 CXCR4 CXCR7 CXCR6

Biological Activity
Purity & Documentation
References
Customer Review

Description

Anditixafortide (Pentixather) is an endoradiotherapeutic vector. Anditixafortide is a CXCR4-targeting peptide derivative^[1]. Anditixafortide can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

IC₅₀ & Target

RDC Peptide

Molecular Weight

1347.26

Formula

C₆₀H₇₉IN₁₄O₁₄

CAS No.

1821136-83-7

Appearance

Solid

Color

White to off-white

Sequence

cyclo(Nal-Gly-(3-I-d-Tyr)-(N-Me-Orn(AMBA-DOTA)))

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (37.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7422 mL	3.7112 mL	7.4225 mL
5 mM	0.1484 mL	0.7422 mL	1.4845 mL
10 mM	0.0742 mL	0.3711 mL	0.7422 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.25%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (255 KB) RP-HPLC (110 KB) MS (194 KB)

Handling Instructions (2659 KB)

References

[1]. Nicolas Lepareur, et al. Clinical Advances and Perspectives in Targeted Radionuclide Therapy. Pharmaceutics. 223, 15, 6. [Content Brief]

[2]. Ken Herrmann, et al. First-in-Human Experience of CXCR4-Directed Endoradiotherapy with 177Lu- and 90Y-Labeled Pentixather in Advanced-Stage Multiple Myeloma with Extensive Intra- and Extramedullary Disease. J Nucl Med. 2016, 57, 2. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.7422 mL	3.7112 mL	7.4225 mL	18.5562 mL
	5 mM	0.1484 mL	0.7422 mL	1.4845 mL	3.7112 mL
	10 mM	0.0742 mL	0.3711 mL	0.7422 mL	1.8556 mL
	15 mM	0.0495 mL	0.2474 mL	0.4948 mL	1.2371 mL
	20 mM	0.0371 mL	0.1856 mL	0.3711 mL	0.9278 mL
	25 mM	0.0297 mL	0.1484 mL	0.2969 mL	0.7422 mL
	30 mM	0.0247 mL	0.1237 mL	0.2474 mL	0.6185 mL