HLA DRB1 Antibody (YA1487)

HLA DRB1 Antibody (YA1487) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1487), targeting HLA DRB1, with a predicted molecular weight of 30 kDa (observed band size: 30 kDa). HLA DRB1 Antibody (YA1487) can be used for WB, IHC-P, ICC/IF experiment in human background.

HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and some alleles have increased frequencies associated with certain diseases or conditions. For example, DRB1*1302 has been related to acute and chronic hepatitis B virus persistence. There are multiple pseudorelated genes of The related gene.

3123

Predicted band size: 30 kDa; Observed band size: 30 kDa

Affinity Chromatography

Non-conjugated

Unmodified

Immunology

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Recombinant, Monoclonal

Rabbit

Human

P01911

WB: 1/500-1/1000;IHC: 1/50-1/100;IF: 1/50-1/200

WB, IHC-P, ICC/IF

Liquid

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG

Endogenous

A synthesized peptide derived from human HLA-Drb1