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  2. Isotope-Labeled Compounds TNF Receptor Interleukin Related
  3. Taurohyodeoxycholic acid-d4 sodium

Taurohyodeoxycholic acid-d4 (sodium) is a deuterated labeled Taurohyodeoxycholic acid (sodium). Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.

For research use only. We do not sell to patients.

Taurohyodeoxycholic acid-d<sub>4</sub> sodium Chemical Structure

Taurohyodeoxycholic acid-d4 sodium Chemical Structure

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Description

Taurohyodeoxycholic acid-d4 (sodium) is a deuterated labeled Taurohyodeoxycholic acid (sodium)[1]. Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Taurohyodeoxycholic acid reduces the size and weight of human gallstones in vitro. Taurohyodeoxycholic acid increases bile flow, bile cholesterol secretion and bile lipid secretion in rats. Co-administration of Taurohyodeoxycholic acid and Taurochenodeoxycholic acid prevented Taurohyodeoxycholic acid-induced hepatotoxicity and increased bile flow and bile acid and phospholipid secretion in rats.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

499.70 (free acid)

Formula

C26H45NO6S.xNa

Unlabeled CAS
SMILES

C[C@@]12[C@]3([H])[C@](C[C@@H]([C@]1([H])C[C@@H](CC2)O)O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCC(NC([2H])([2H])C([2H])([2H])S(=O)(O)=O)=O)C.[Na].[x]

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O : 62.5 mg/mL (Need ultrasonic)

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Product Name:
Taurohyodeoxycholic acid-d4 sodium
Cat. No.:
HY-114360AS1
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