Antimalarial agent 14

Name: Antimalarial agent 14
Brand: MedChemExpress
SKU: HY-114197
Rating: 4.5 (1 reviews)

Cat. No.: HY-114197 Purity: 99.33%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Antimalarial agent 14 (Compound N3) is a potent inhibitor of mitochondrial electron transport. Antimalarial agent 14 can serve as an anti-malarial agent.

For research use only. We do not sell to patients.

Antimalarial agent 14 Chemical Structure

CAS No. : 1150-59-0

Size	Price	Stock	Quantity
5 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 620	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 860	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1150	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Antimalarial agent 14 (Compound N3) is a potent inhibitor of mitochondrial electron transport. Antimalarial agent 14 can serve as an anti-malarial agent^[1].

IC₅₀ & Target

Plasmodium

In Vitro

Antimalarial agent 14 (Compound N3) (0-400 μM, 48 h) inhibits P. falciparum with limited cytotoxicity against human cells^[1].
Antimalarial agent 14 inhibits P. falciparum mitochondrial membrane potential with an IC_50ΔΨmit of 16 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	P. falciparum and HEK293T
Concentration:	0.128, 0.64, 3.2, 16, 80 and 400 μM
Incubation Time:	48 h
Result:	Showed inhibition with an IC₅₀ of 443 nM against P. falciparum and showed cytotoxicity with a CC₅₀ of 54.6 ± 0.23 μM.

Molecular Weight

250.25

Formula

C₁₆H₁₀O₃

CAS No.

1150-59-0

Appearance

Solid

Color

Yellow to brown

SMILES

O=C1C(O)=C(C2=CC=CC=C2)C(C3=C1C=CC=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (499.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.9960 mL	19.9800 mL	39.9600 mL
5 mM	0.7992 mL	3.9960 mL	7.9920 mL
10 mM	0.3996 mL	1.9980 mL	3.9960 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.33%

Select Batch:

Data Sheet (296 KB) SDS (392 KB)

COA (253 KB) HNMR (251 KB) LCMS (91 KB)

Handling Instructions (2659 KB)

References

[1]. Schuck DC, et al. Biological evaluation of hydroxynaphthoquinones as anti-malarials. Malar J. 2013 Jul 10;12:234. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.9960 mL	19.9800 mL	39.9600 mL	99.9001 mL
	5 mM	0.7992 mL	3.9960 mL	7.9920 mL	19.9800 mL
	10 mM	0.3996 mL	1.9980 mL	3.9960 mL	9.9900 mL
	15 mM	0.2664 mL	1.3320 mL	2.6640 mL	6.6600 mL
	20 mM	0.1998 mL	0.9990 mL	1.9980 mL	4.9950 mL
	25 mM	0.1598 mL	0.7992 mL	1.5984 mL	3.9960 mL
	30 mM	0.1332 mL	0.6660 mL	1.3320 mL	3.3300 mL
	40 mM	0.0999 mL	0.4995 mL	0.9990 mL	2.4975 mL
	50 mM	0.0799 mL	0.3996 mL	0.7992 mL	1.9980 mL
	60 mM	0.0666 mL	0.3330 mL	0.6660 mL	1.6650 mL
	80 mM	0.0500 mL	0.2498 mL	0.4995 mL	1.2488 mL
	100 mM	0.0400 mL	0.1998 mL	0.3996 mL	0.9990 mL