Antiproliferative agent-14

Name: Antiproliferative agent-14
Brand: MedChemExpress
SKU: HY-148265
Rating: 4.5 (1 reviews)

Cat. No.: HY-148265 Purity: 98.76%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Antiproliferative agent-14 (compound 3b) a potent tubulin polymerization inhibitor, with an IC₅₀ of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the ability to arrest cells at G2/M phases of the cell cycle.

For research use only. We do not sell to patients.

Antiproliferative agent-14 Chemical Structure

CAS No. : 1885900-35-5

Size	Price	Stock	Quantity
5 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 560	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 890	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1350	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	0.013 μM Compound: 3b	Cytotoxicity against human HeLa cells after 3 days by SRB assay Cytotoxicity against human HeLa cells after 3 days by SRB assay	[PMID: 26927488]

In Vitro

Antiproliferative agent-14 (compound 3b) shows antiproliferative activity against HeLa cell (IC₅₀=13 nM)^[1].
Antiproliferative agent-14 shows inhibition of colchicine binding activity, with 72.2% inhibitory percentage^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

363.38

Formula

C₂₁H₁₈FN₃O₂

CAS No.

1885900-35-5

Appearance

Solid

Color

Light yellow to yellow

SMILES

COC1=CC=C(C=C1)CNC2=C(N=C3C=CC(F)=CN32)C4=C(C=CC=C4)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (275.19 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7519 mL	13.7597 mL	27.5194 mL
5 mM	0.5504 mL	2.7519 mL	5.5039 mL
10 mM	0.2752 mL	1.3760 mL	2.7519 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.76%

Select Batch:

Data Sheet (278 KB) SDS (251 KB)

COA (258 KB) HNMR (256 KB) LCMS (268 KB)

Handling Instructions (2659 KB)

References

[1]. An W, et al. Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents. Eur J Med Chem. 2016 Apr 13;112:367-372. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7519 mL	13.7597 mL	27.5194 mL	68.7985 mL
	5 mM	0.5504 mL	2.7519 mL	5.5039 mL	13.7597 mL
	10 mM	0.2752 mL	1.3760 mL	2.7519 mL	6.8799 mL
	15 mM	0.1835 mL	0.9173 mL	1.8346 mL	4.5866 mL
	20 mM	0.1376 mL	0.6880 mL	1.3760 mL	3.4399 mL
	25 mM	0.1101 mL	0.5504 mL	1.1008 mL	2.7519 mL
	30 mM	0.0917 mL	0.4587 mL	0.9173 mL	2.2933 mL
	40 mM	0.0688 mL	0.3440 mL	0.6880 mL	1.7200 mL
	50 mM	0.0550 mL	0.2752 mL	0.5504 mL	1.3760 mL
	60 mM	0.0459 mL	0.2293 mL	0.4587 mL	1.1466 mL
	80 mM	0.0344 mL	0.1720 mL	0.3440 mL	0.8600 mL
	100 mM	0.0275 mL	0.1376 mL	0.2752 mL	0.6880 mL