Ardisiacrispin B

Cat. No.: HY-N8198 Purity: 99.49%: FAQs
Data Sheet SDS COA Handling Instructions

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Ardisiacrispin B displays cytotoxic effects in multi-factorial agent resistant cancer cells via ferroptotic and apoptotic cell death.

For research use only. We do not sell to patients.

Ardisiacrispin B Chemical Structure

CAS No. : 112766-96-8

Size	Price	Stock	Quantity
5 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Ardisiacrispin B displays cytotoxic effects in multi-factorial agent resistant cancer cells via ferroptotic and apoptotic cell death^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.6 μM Compound: 10, ardisiacrispin B	Cytotoxicity against human A549 cell line by MTT assay Cytotoxicity against human A549 cell line by MTT assay	[PMID: 17243725]
Bel-7402	IC₅₀	4.46 mM Compound: 9	Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay Cytotoxicity against human Bel7402 cells after 72 hrs by MTT assay	[PMID: 22940450]
HepG2	IC₅₀	1.53 μM Compound: 12	Cytotoxic activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
HepG2	IC₅₀	20.96 mM Compound: 9	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 22940450]
HL-60	IC₅₀	22.58 μM Compound: 12	Cytotoxic activity against human HL60 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human HL60 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
HL-60	IC₅₀	3.2 μM Compound: 10, ardisiacrispin B	Cytotoxicity against human HL60 cell line by MTT assay Cytotoxicity against human HL60 cell line by MTT assay	[PMID: 17243725]
KB	IC₅₀	1.6 μM Compound: 12	Cytotoxic activity against human KB cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human KB cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
L02	IC₅₀	> 100 mM Compound: 9	Cytotoxicity against human HL-7702 cells after 72 hrs by MTT assay Cytotoxicity against human HL-7702 cells after 72 hrs by MTT assay	[PMID: 22940450]
LNCaP	IC₅₀	9.7 μM Compound: 12	Cytotoxic activity against human LNCAP cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human LNCAP cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
Lu1	IC₅₀	1.41 μM Compound: 12	Cytotoxic activity against human Lu1 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human Lu1 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
MDA-MB-231	IC₅₀	11.76 μM Compound: 12	Cytotoxic activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
MKN-7	IC₅₀	1.27 μM Compound: 12	Cytotoxic activity against human MKN7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human MKN7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
SW480	IC₅₀	1.24 μM Compound: 12	Cytotoxic activity against human SW480 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human SW480 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]

Molecular Weight

1075.24

Formula

C₅₃H₈₆O₂₂

CAS No.

112766-96-8

Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@]3(CC[C@@]4([H])[C@]2(CC[C@]5([H])[C@@]4(CC[C@@H](C5(C)C)O[C@H]6[C@@H]([C@H]([C@H](CO6)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O)O)O[C@H]8[C@@H]([C@@H]([C@H]([C@@H](O8)C)O)O)O)O)O[C@@H]9O[C@@H]([C@H]([C@@H]([C@H]9O)O)O)CO)C)C)[C@@]%10([H])[C@@]([C@@H](C1)O)(CC[C@@](C)(C%10)C=O)CO3

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (93.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.9300 mL	4.6501 mL	9.3002 mL
5 mM	0.1860 mL	0.9300 mL	1.8600 mL
10 mM	0.0930 mL	0.4650 mL	0.9300 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.49%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (259 KB) RP-HPLC (253 KB)

Handling Instructions (2659 KB)

References

[1]. Armelle T Mbaveng, et al. A naturally occuring triterpene saponin ardisiacrispin B displayed cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death. Phytomedicine. 2018 Apr 1;43:78-85. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.9300 mL	4.6501 mL	9.3002 mL	23.2506 mL
	5 mM	0.1860 mL	0.9300 mL	1.8600 mL	4.6501 mL
	10 mM	0.0930 mL	0.4650 mL	0.9300 mL	2.3251 mL
	15 mM	0.0620 mL	0.3100 mL	0.6200 mL	1.5500 mL
	20 mM	0.0465 mL	0.2325 mL	0.4650 mL	1.1625 mL
	25 mM	0.0372 mL	0.1860 mL	0.3720 mL	0.9300 mL
	30 mM	0.0310 mL	0.1550 mL	0.3100 mL	0.7750 mL
	40 mM	0.0233 mL	0.1163 mL	0.2325 mL	0.5813 mL
	50 mM	0.0186 mL	0.0930 mL	0.1860 mL	0.4650 mL
	60 mM	0.0155 mL	0.0775 mL	0.1550 mL	0.3875 mL
	80 mM	0.0116 mL	0.0581 mL	0.1163 mL	0.2906 mL