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  4. Argifin

Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC50s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively.

For research use only. We do not sell to patients.

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Argifin Chemical Structure

Argifin Chemical Structure

CAS No. : 243975-37-3

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1 mg USD 120 In-stock
5 mg USD 336 In-stock
10 mg USD 520 In-stock
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Based on 1 publication(s) in Google Scholar

Argifin Related Antibodies

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Description

Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC50s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively[1].

IC50 & Target

IC50: 0.025 μM (SmChiA), 6.4 μM (SmChiB), 1.1 μM (Aspergillus fumigatus chitinase B1), 4.5 μM (human chitotriosidase)[1]
In Vitro

Argifin inhibits L. cuprina chitinase with IC50 values of 3.7 μM at 37 ºC and 0.10 μM at 20 ºC[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Argifin Related Antibodies
In Vivo

Argifin has the ability to inhibit L. cuprina molting[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

675.69

Formula

C29H41N9O10
CAS No.
Appearance

Solid

Color

White to off-white

Structure Classification
Initial Source

Gliocladium sp
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (148.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4800 mL 7.3998 mL 14.7997 mL
5 mM 0.2960 mL 1.4800 mL 2.9599 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4800 mL 7.3998 mL 14.7997 mL 36.9992 mL
5 mM 0.2960 mL 1.4800 mL 2.9599 mL 7.3998 mL
10 mM 0.1480 mL 0.7400 mL 1.4800 mL 3.6999 mL
15 mM 0.0987 mL 0.4933 mL 0.9866 mL 2.4666 mL
20 mM 0.0740 mL 0.3700 mL 0.7400 mL 1.8500 mL
25 mM 0.0592 mL 0.2960 mL 0.5920 mL 1.4800 mL
30 mM 0.0493 mL 0.2467 mL 0.4933 mL 1.2333 mL
40 mM 0.0370 mL 0.1850 mL 0.3700 mL 0.9250 mL
50 mM 0.0296 mL 0.1480 mL 0.2960 mL 0.7400 mL
60 mM 0.0247 mL 0.1233 mL 0.2467 mL 0.6167 mL
80 mM 0.0185 mL 0.0925 mL 0.1850 mL 0.4625 mL
100 mM 0.0148 mL 0.0740 mL 0.1480 mL 0.3700 mL
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Argifin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Argifin243975-37-3ParasitechitinaseSmChiASmChiBchitotriosidaseInhibitorinhibitorinhibit

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