ASN02563583

Cat. No.: HY-128111 Purity: 99.21%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

ASN02563583, a compound that regulates the activity of the GPR17 receptor, has a IC₅₀ value of 0.64 nM in [₃₅S]GTPγS binding assay. ASN02563583 can be used in the study of neurological diseases.

For research use only. We do not sell to patients.

ASN02563583 Chemical Structure

CAS No. : 483283-39-2

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 230	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 370	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 780	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1250	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

460.55

Formula

C₂₅H₂₄N₄O₃S

CAS No.

483283-39-2

Appearance

Solid

Color

White to off-white

SMILES

CC(SC1=NN=C(C2=CC=CC=C2OC)N1C3=CC=C(OC)C=C3)C(NC4=CC=CC=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (217.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1713 mL	10.8566 mL	21.7132 mL
5 mM	0.4343 mL	2.1713 mL	4.3426 mL
10 mM	0.2171 mL	1.0857 mL	2.1713 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 5 mg/mL (10.86 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: 5 mg/mL (10.86 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 5 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.21%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (254 KB) HNMR (146 KB) RP-HPLC (140 KB) LCMS (106 KB)

Handling Instructions (2659 KB)

References

[1]. Mariapia Abbracchio, et al. TGpr17-modulating compounds, diagnostic and therapeutic uses thereof. US20140148472A1. 2014-05-29.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1713 mL	10.8566 mL	21.7132 mL	54.2829 mL
	5 mM	0.4343 mL	2.1713 mL	4.3426 mL	10.8566 mL
	10 mM	0.2171 mL	1.0857 mL	2.1713 mL	5.4283 mL
	15 mM	0.1448 mL	0.7238 mL	1.4475 mL	3.6189 mL
	20 mM	0.1086 mL	0.5428 mL	1.0857 mL	2.7141 mL
	25 mM	0.0869 mL	0.4343 mL	0.8685 mL	2.1713 mL
	30 mM	0.0724 mL	0.3619 mL	0.7238 mL	1.8094 mL
	40 mM	0.0543 mL	0.2714 mL	0.5428 mL	1.3571 mL
	50 mM	0.0434 mL	0.2171 mL	0.4343 mL	1.0857 mL
	60 mM	0.0362 mL	0.1809 mL	0.3619 mL	0.9047 mL
	80 mM	0.0271 mL	0.1357 mL	0.2714 mL	0.6785 mL
	100 mM	0.0217 mL	0.1086 mL	0.2171 mL	0.5428 mL

ASN02563583 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ASN02563583483283-39-2ASN 02563583ASN-02563583OthersGPR17ModulatorNeurological diseaseInhibitorinhibitorinhibit

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