2. GPCR/G Protein
  3. Oxytocin Receptor
  4. [Asp5]-Oxytocin

[Asp5]-Oxytocin is the first 5-position neurohypophyseal hormone analogue possessing significant biological activity. [Asp5]-Oxytocin causes uterine contractions in vitro, enhanced by Mg2+. [Asp5]-Oxytocin has the ability of rat uteroconstrictor, avian vasodilator, and rat antidiuretic.

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Custom Peptide Synthesis

[Asp5]-Oxytocin Chemical Structure

[Asp5]-Oxytocin Chemical Structure

CAS No. : 65907-78-0

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1 mg USD 150 In-stock
5 mg USD 290 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of [Asp5]-Oxytocin:

[Asp5]-Oxytocin Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

[Asp5]-Oxytocin is the first 5-position neurohypophyseal hormone analogue possessing significant biological activity. [Asp5]-Oxytocin causes uterine contractions in vitro, enhanced by Mg2+. [Asp5]-Oxytocin has the ability of rat uteroconstrictor, avian vasodilator, and rat antidiuretic[1].

In Vitro

[Asp5]-Oxytocin retains not only a high affinity for the uterotonic receptor, but also an intrinsic activity identical with that of oxytocin[1].
[Asp5]-Oxytocin displays an increasing intrinsic activity enhanced by 1 mM Mg2+[1].
[Asp5]-Oxytocin exerts the same potencies of rat uterotonic, avian vasodepressor, and rat antidiuretic with 20.3, 41, and 0.14 units/mg dose[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

[Asp5]-Oxytocin Related Antibodies
Molecular Weight

1008.17

Formula

C43H65N11O13S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

CYIQDCPLG-NH2 (Disulfide bridge:Cys1-Cys6)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (99.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9919 mL 4.9595 mL 9.9190 mL
5 mM 0.1984 mL 0.9919 mL 1.9838 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.19%

COA (266 KB) RP-HPLC (86 KB) MS (243 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9919 mL 4.9595 mL 9.9190 mL 24.7974 mL
5 mM 0.1984 mL 0.9919 mL 1.9838 mL 4.9595 mL
10 mM 0.0992 mL 0.4959 mL 0.9919 mL 2.4797 mL
15 mM 0.0661 mL 0.3306 mL 0.6613 mL 1.6532 mL
20 mM 0.0496 mL 0.2480 mL 0.4959 mL 1.2399 mL
25 mM 0.0397 mL 0.1984 mL 0.3968 mL 0.9919 mL
30 mM 0.0331 mL 0.1653 mL 0.3306 mL 0.8266 mL
40 mM 0.0248 mL 0.1240 mL 0.2480 mL 0.6199 mL
50 mM 0.0198 mL 0.0992 mL 0.1984 mL 0.4959 mL
60 mM 0.0165 mL 0.0827 mL 0.1653 mL 0.4133 mL
80 mM 0.0124 mL 0.0620 mL 0.1240 mL 0.3100 mL
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[Asp5]-Oxytocin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[Asp5]-Oxytocin65907-78-0Oxytocin ReceptorOXTRInhibitorinhibitorinhibit

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