Astin B 

Astin B is a orally active and potent cyclic pentapeptide, that can be isolated from Aster tataricus. Astin B has hepatotoxic effects in vitro and in vivo and that hepatic injury was primarily mediated by apoptosis in a mitochondria/caspase-dependent manner. Astin B induces autophagy in L-02 cells, increases LC3-II and decreases p62 expression^[1].

Astin B (0-60 μM, 12-48 h) inhabits proliferation of L-02 cells^[1].
Astin B (0-60 μM, 24 h) induces oxidative stress and mitochondrial dysfunction, regulates Bcl-2/Bax expression and increases caspase-3 and -9 activity^[1].
Astin B (0-60 μM, 24 h) induces autophagy in L-02 cells to protect from apoptosis^[1].
Astin B provokes oxidative stress-associated inflammation in hepatocytes as evidenced by increased levels of reactive oxygen species (ROS), reduced contents of intracellular glutathione (GSH), and enhanced phosphorylation of c-Jun N-terminal kinase (JNK)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Astin B (10 mg/kg, Orally, once daily for 7 consecutive days) induces liver injury in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

586.46

C₂₅H₃₃Cl₂N₅O₇

151201-76-2

Cl[C@H](C1)[C@@H](Cl)[C@@](N1C([C@H](CC)NC(C[C@H](C2=CC=CC=C2)N3)=O)=O)([H])C(N[C@H]([C@H](C)O)C(N[C@@H](CO)C3=O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang L, et al. Astin B, a cyclic pentapeptide from Aster tataricus, induces apoptosis and autophagy in human hepatic L-02 cells. Chem Biol Interact. 2014 Nov 5;223:1-9.  [Content Brief]