ATPγS tetralithium salt (Synonyms: Adenosine-5'-O-3-thiotriphosphate (tetralithium salt); Adenosine 5'-[γ-thio]triphosphate tetralithium salt)

Name: ATPγS tetralithium salt
Brand: MedChemExpress
SKU: HY-108666
Rating: 4.5 (1 reviews)

Cat. No.: HY-108666 Purity: 94.15%: FAQs
Data Sheet SDS COA Handling Instructions

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ATPγS (tetralithium salt) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A.

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ATPγS tetralithium salt Chemical Structure

CAS No. : 93839-89-5

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Based on 1 publication(s) in Google Scholar

Other Forms of ATPγS tetralithium salt:

ATP-γ-S tetrasodium Get quote

1 Publications Citing Use of MCE ATPγS tetralithium salt

•J Adv Res. 2022 Dec 13;S2090-1232(22)00285-5. [Abstract]

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Description

ATPγS (tetralithium salt) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A^[1].

IC₅₀ & Target

eIF4

In Vitro

ATPγS (tetralithium salt) enhances intrinsic fluorescence and induces aggregation which increases the activity of spinach Rubisco activase^[1].
ATPγS (50-100 μM final blood concentration) attenuates inflammatory response with decreased accumulation of cells (48%, P < 0.01) and proteins (57%, P < 0.01) in bronchoalveolar lavage and reduces neutrophil infiltration and extravasation of Evans blue albumin dye into lung tissue^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ATPγS (tetralithium salt, 50 μM final, intravenous) demonstrates preserved lung parenchymal architecture^[3].
ATPγS results in a dose-dependent effect on EBA extravasation in LPS-treated mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

546.98

Formula

C₁₀H₁₂Li₄N₅O₁₂P₃S

CAS No.

93839-89-5

Appearance

Solid

Color

White to light yellow

SMILES

O[C@H]1[C@@H](O[C@H](COP(OP(OP(O[Li])(O[Li])=S)(O[Li])=O)(O[Li])=O)[C@H]1O)N2C3=C(C(N)=NC=N3)N=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (182.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 75 mg/mL (137.12 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8282 mL	9.1411 mL	18.2822 mL
5 mM	0.3656 mL	1.8282 mL	3.6564 mL
10 mM	0.1828 mL	0.9141 mL	1.8282 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.57 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (276 KB) SDS (394 KB)

COA (250 KB)

Handling Instructions (2659 KB)

References

[1]. Matthew L Peck, et al. Adenosine 5'-O-(3-thio)triphosphate (ATPgammaS) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. RNA. 2003 Oct;9(10):1180-7. [Content Brief]

[2]. Z Y Wang, et al. Mg2+ and ATP or adenosine 5'-[gamma-thio]-triphosphate (ATP gamma S) enhances intrinsic fluorescence and induces aggregation which increases the activity of spinach Rubisco activase. Biochim Biophys Acta. 1993 Sep 3;1202(1):47-55. [Content Brief]

[3]. Irina A Kolosova, et al. Protective effect of purinergic agonist ATPgammaS against acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294(2):L319-24. [Content Brief]

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.8282 mL	9.1411 mL	18.2822 mL	45.7055 mL
	5 mM	0.3656 mL	1.8282 mL	3.6564 mL	9.1411 mL
	10 mM	0.1828 mL	0.9141 mL	1.8282 mL	4.5706 mL
	15 mM	0.1219 mL	0.6094 mL	1.2188 mL	3.0470 mL
	20 mM	0.0914 mL	0.4571 mL	0.9141 mL	2.2853 mL
	25 mM	0.0731 mL	0.3656 mL	0.7313 mL	1.8282 mL
	30 mM	0.0609 mL	0.3047 mL	0.6094 mL	1.5235 mL
	40 mM	0.0457 mL	0.2285 mL	0.4571 mL	1.1426 mL
	50 mM	0.0366 mL	0.1828 mL	0.3656 mL	0.9141 mL
	60 mM	0.0305 mL	0.1524 mL	0.3047 mL	0.7618 mL
	80 mM	0.0229 mL	0.1143 mL	0.2285 mL	0.5713 mL
	100 mM	0.0183 mL	0.0914 mL	0.1828 mL	0.4571 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

ATPγS tetralithium salt Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATPγS tetralithium93839-89-5Adenosine-5'-O-3-thiotriphosphate tetralithiumAdenosine 5'-[γ-thio]triphosphate tetralithiumEukaryotic Initiation Factor (eIF)eIF4AEBAlungparenchymalarchitectureInhibitorinhibitorinhibit

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ATPγS tetralithium salt (Synonyms: Adenosine-5'-O-3-thiotriphosphate (tetralithium salt); Adenosine 5'-[γ-thio]triphosphate tetralithium salt)

Customer Review

Other Forms of ATPγS tetralithium salt:

ATPγS tetralithium salt Related Antibodies

1 Publications Citing Use of MCE ATPγS tetralithium salt

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

ATPγS tetralithium salt Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

ATPγS tetralithium salt Related Classifications

Keywords:

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