2. Autophagy PROTAC
  3. AUTACs Autophagy
  4. AUTAC2-2G

AUTAC2-2G is a second-generation AUTAC with a 100-fold increase in activity.

For research use only. We do not sell to patients.

AUTAC2-2G Chemical Structure

AUTAC2-2G Chemical Structure

Size Price Stock Quantity
1 mg USD 256 In-stock
5 mg USD 640 In-stock
10 mg USD 1020 In-stock
25 mg USD 2050 In-stock
50 mg USD 3280 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

AUTAC2-2G Related Antibodies

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Description

AUTAC2-2G is a second-generation AUTAC with a 100-fold increase in activity[1].

Molecular Weight

1135.29

Formula

C59H75FN10O12
Appearance

Solid

Color

White to off-white

SMILES

CCC(C)(C(C(N1CCCC[C@H]1C(O[C@@H](C2=CC(NC(CCC(NCCCOCCOCCOCCCN3C=C(C=N3)C4=NC5=C(N4CC6=CC=C(C=C6)F)N=C(NC5=O)N)=O)=O)=CC=C2)CCC7=CC(OC)=C(C=C7)OC)=O)=O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (88.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8808 mL 4.4042 mL 8.8083 mL
5 mM 0.1762 mL 0.8808 mL 1.7617 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8808 mL 4.4042 mL 8.8083 mL 22.0208 mL
5 mM 0.1762 mL 0.8808 mL 1.7617 mL 4.4042 mL
10 mM 0.0881 mL 0.4404 mL 0.8808 mL 2.2021 mL
15 mM 0.0587 mL 0.2936 mL 0.5872 mL 1.4681 mL
20 mM 0.0440 mL 0.2202 mL 0.4404 mL 1.1010 mL
25 mM 0.0352 mL 0.1762 mL 0.3523 mL 0.8808 mL
30 mM 0.0294 mL 0.1468 mL 0.2936 mL 0.7340 mL
40 mM 0.0220 mL 0.1101 mL 0.2202 mL 0.5505 mL
50 mM 0.0176 mL 0.0881 mL 0.1762 mL 0.4404 mL
60 mM 0.0147 mL 0.0734 mL 0.1468 mL 0.3670 mL
80 mM 0.0110 mL 0.0551 mL 0.1101 mL 0.2753 mL
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AUTAC2-2G Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AUTAC2-2GAUTACsAutophagyAutophagy-targeting chimerasInhibitorinhibitorinhibit

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