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  4. AV-105

AV-105 is a Florbetapir (18F)-radiolabeled slyrylpyridine tosylate precursor extracted from patent WO2010078370A1, example 1.5. AV-105 can synthesize 18F-radiolabeled compounds, which are used for positron emission tomography (PET) imaging of neurodegenerative diseases of the brain.

For research use only. We do not sell to patients.

AV-105 Chemical Structure

AV-105 Chemical Structure

CAS No. : 1205550-99-7

Size Price Stock Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 121 In-stock
Solution
10 mM * 1 mL in DMSO USD 121 In-stock
Liquid
5 mg USD 70 In-stock
10 mg USD 110 In-stock
50 mg USD 320 In-stock
100 mg USD 520 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

AV-105 Related Antibodies

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Description

AV-105 is a Florbetapir (18F)-radiolabeled slyrylpyridine tosylate precursor extracted from patent WO2010078370A1, example 1.5. AV-105 can synthesize 18F-radiolabeled compounds, which are used for positron emission tomography (PET) imaging of neurodegenerative diseases of the brain[1].

In Vitro

The AV-105 synthesis method utilizes a primary tosylate instead of a primary mesylate as an active leaving group. Use of the tosylate precursor for radiofluorination is beneficial, at least for the reason that the tosylate generated during the radiofluorination reaction is readily removed by chromatographic means from the 18F-radiolabeled imaging product[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AV-105 Related Antibodies
Molecular Weight

612.73

Formula

C32H40N2O8S
CAS No.
Appearance

Liquid (Density: 1.221±0.06 g/cm3)

Color

White to yellow

SMILES

O=C(OC(C)(C)C)N(C)C1=CC=C(/C=C/C2=CC=C(OCCOCCOCCOS(=O)(C3=CC=C(C)C=C3)=O)N=C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (102.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6320 mL 8.1602 mL 16.3204 mL
5 mM 0.3264 mL 1.6320 mL 3.2641 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.70%

COA (248 KB) HNMR (376 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6320 mL 8.1602 mL 16.3204 mL 40.8010 mL
5 mM 0.3264 mL 1.6320 mL 3.2641 mL 8.1602 mL
10 mM 0.1632 mL 0.8160 mL 1.6320 mL 4.0801 mL
15 mM 0.1088 mL 0.5440 mL 1.0880 mL 2.7201 mL
20 mM 0.0816 mL 0.4080 mL 0.8160 mL 2.0401 mL
25 mM 0.0653 mL 0.3264 mL 0.6528 mL 1.6320 mL
30 mM 0.0544 mL 0.2720 mL 0.5440 mL 1.3600 mL
40 mM 0.0408 mL 0.2040 mL 0.4080 mL 1.0200 mL
50 mM 0.0326 mL 0.1632 mL 0.3264 mL 0.8160 mL
60 mM 0.0272 mL 0.1360 mL 0.2720 mL 0.6800 mL
80 mM 0.0204 mL 0.1020 mL 0.2040 mL 0.5100 mL
100 mM 0.0163 mL 0.0816 mL 0.1632 mL 0.4080 mL
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AV-105 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AV-1051205550-99-7AV105AV 105OthersFlorbetapirbrainimagingadiolabeledtosylateprecursorAlzheimer'sDiseaseInhibitorinhibitorinhibit

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