2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. AXC-715 trihydrochloride

AXC-715 trihydrochloride  (Synonyms: T785 trihydrochloride)

Cat. No.: HY-138139B Purity: 99.83%
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AXC-715 (T785) trihydrochloride is a TLR7/TLR8 dual agonist, extracted from patent WO2020168017 A1. AXC-715 trihydrochloride, compound D from WO2020190734A1, can be used for synthesis of antibody-adjuvant immunoconjugates, comprising an antibody construct that binds programmed death-ligand 1 (PD-L1) linked to one or more adjuvants.

For research use only. We do not sell to patients.

AXC-715 trihydrochloride Chemical Structure

AXC-715 trihydrochloride Chemical Structure

CAS No. : 2479276-17-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 418 In-stock
Solution
10 mM * 1 mL in DMSO USD 418 In-stock
Solid
5 mg USD 380 In-stock
10 mg USD 620 In-stock
25 mg USD 1250 In-stock
50 mg USD 2000 In-stock
100 mg USD 3200 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of AXC-715 trihydrochloride:

AXC-715 trihydrochloride Related Antibodies

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

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Description

AXC-715 (T785) trihydrochloride is a TLR7/TLR8 dual agonist, extracted from patent WO2020168017 A1[1]. AXC-715 trihydrochloride, compound D from WO2020190734A1, can be used for synthesis of antibody-adjuvant immunoconjugates, comprising an antibody construct that binds programmed death-ligand 1 (PD-L1) linked to one or more adjuvants[2].

IC50 & Target

TLR7/TLR8[1]
Molecular Weight

420.81

Formula

C18H28Cl3N5
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

NC1=NC2=C(C=CC=C2)C3=C1N=C(CCCC)N3CCCCN.Cl.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (297.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3764 mL 11.8818 mL 23.7637 mL
5 mM 0.4753 mL 2.3764 mL 4.7527 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3764 mL 11.8818 mL 23.7637 mL 59.4092 mL
5 mM 0.4753 mL 2.3764 mL 4.7527 mL 11.8818 mL
10 mM 0.2376 mL 1.1882 mL 2.3764 mL 5.9409 mL
15 mM 0.1584 mL 0.7921 mL 1.5842 mL 3.9606 mL
20 mM 0.1188 mL 0.5941 mL 1.1882 mL 2.9705 mL
25 mM 0.0951 mL 0.4753 mL 0.9505 mL 2.3764 mL
30 mM 0.0792 mL 0.3961 mL 0.7921 mL 1.9803 mL
40 mM 0.0594 mL 0.2970 mL 0.5941 mL 1.4852 mL
50 mM 0.0475 mL 0.2376 mL 0.4753 mL 1.1882 mL
60 mM 0.0396 mL 0.1980 mL 0.3961 mL 0.9902 mL
80 mM 0.0297 mL 0.1485 mL 0.2970 mL 0.7426 mL
100 mM 0.0238 mL 0.1188 mL 0.2376 mL 0.5941 mL
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AXC-715 trihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AXC-715 trihydrochloride2479276-17-8T785 trihydrochlorideToll-like Receptor (TLR)Inhibitorinhibitorinhibit

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