2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. AXC-715 hydrochloride

AXC-715 hydrochloride  (Synonyms: T785 hydrochloride)

Cat. No.: HY-138139A Purity: 99.46%
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AXC-715 (T785) hydrochloride is a TLR7/TLR8 dual agonist, extracted from patent WO2020168017 A1. AXC-715, compound D from WO2020190734A1, can be used for synthesis of antibody-adjuvant immunoconjugates, comprising an antibody construct that binds programmed death-ligand 1 (PD-L1) linked to one or more adjuvants.

For research use only. We do not sell to patients.

AXC-715 hydrochloride Chemical Structure

AXC-715 hydrochloride Chemical Structure

CAS No. : 2490497-93-1

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5 mg USD 380 In-stock
10 mg USD 620 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of AXC-715 hydrochloride:

AXC-715 hydrochloride Related Antibodies

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

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Description

AXC-715 (T785) hydrochloride is a TLR7/TLR8 dual agonist, extracted from patent WO2020168017 A1[1]. AXC-715, compound D from WO2020190734A1, can be used for synthesis of antibody-adjuvant immunoconjugates, comprising an antibody construct that binds programmed death-ligand 1 (PD-L1) linked to one or more adjuvants[2].

IC50 & Target[1]

TLR8

 

TLR7

 

Molecular Weight

347.89

Formula

C18H26ClN5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

NCCCCN1C(CCCC)=NC2=C1C3=CC=CC=C3N=C2N.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (143.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8745 mL 14.3724 mL 28.7447 mL
5 mM 0.5749 mL 2.8745 mL 5.7489 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8745 mL 14.3724 mL 28.7447 mL 71.8618 mL
5 mM 0.5749 mL 2.8745 mL 5.7489 mL 14.3724 mL
10 mM 0.2874 mL 1.4372 mL 2.8745 mL 7.1862 mL
15 mM 0.1916 mL 0.9582 mL 1.9163 mL 4.7908 mL
20 mM 0.1437 mL 0.7186 mL 1.4372 mL 3.5931 mL
25 mM 0.1150 mL 0.5749 mL 1.1498 mL 2.8745 mL
30 mM 0.0958 mL 0.4791 mL 0.9582 mL 2.3954 mL
40 mM 0.0719 mL 0.3593 mL 0.7186 mL 1.7965 mL
50 mM 0.0575 mL 0.2874 mL 0.5749 mL 1.4372 mL
60 mM 0.0479 mL 0.2395 mL 0.4791 mL 1.1977 mL
80 mM 0.0359 mL 0.1797 mL 0.3593 mL 0.8983 mL
100 mM 0.0287 mL 0.1437 mL 0.2874 mL 0.7186 mL
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AXC-715 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AXC-7152490497-93-1T785AXC715AXC 715T 785T-785Toll-like Receptor (TLR)Inhibitorinhibitorinhibit

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