2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. AZD0022

AZD0022 is a selective and orally active KRASG12D inhibitor. AZD0022 inhibits KRAS pathway suppression in the GP2D xenograft model.

For research use only. We do not sell to patients.

AZD0022 Chemical Structure

AZD0022 Chemical Structure

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AZD0022 Related Antibodies

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Description

AZD0022 is a selective and orally active KRASG12D inhibitor. AZD0022 inhibits KRAS pathway suppression in the GP2D xenograft model[1].

IC50 & Target[1]

KRas G12D

 

In Vivo

Blood clearance of AZD0022 was 8.2 and 8.6 mL/min/kg in mice and dogs, respectively[1].
In the GP2D model, single oral 150 mg/kg doses displays prolonged plasma and tumour exposure. AZD0022 is estimated to be 18x more bound in tumour tissue than in plasma. Seven days of continuous 150mg/kg BID dosing resulted in up to approx. 75% pRSK inhibition. A dose range of 10, 50 and 150 mg/kg BID over 7 days display exposure-dependent pRSK modulation, with maximal of 75% pRSK inhibition[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

614.64

Formula

C34H30F4N6O
SMILES

FC1=C(C#C)C2=C(C=C(N)C=C2C3=C(F)C(N=C(OCC4(C[C@@H](F)C5)N5CCC4)N=C6N7C[C@H]8N[C@H](C=C8)C7)=C6C=C3F)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AZD0022 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZD0022AZD 0022AZD-0022RasKRASG12D inhibitorInhibitorinhibitorinhibit

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AZD0022
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HY-173637
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