2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. AZD4144

AZD4144 is an orally active NLRP3 inhibitor.

For research use only. We do not sell to patients.

AZD4144 Chemical Structure

AZD4144 Chemical Structure

CAS No. : 2890191-41-8

Size Price Stock Quantity
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

AZD4144 Related Antibodies

Top Publications Citing Use of Products

View All NOD-like Receptor (NLR) Isoform Specific Products:

View All Isoforms
NLRP3 NLRP1 NOD1 NOD2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

AZD4144 is an orally active NLRP3 inhibitor[1].
Molecular Weight

379.33

Formula

C18H16F3N3O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

OC1=C(C2=C(C=CC=C3)C3=C(NC[C@H](O)CO)N=N2)C=CC(C(F)(F)F)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (329.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6362 mL 13.1811 mL 26.3623 mL
5 mM 0.5272 mL 2.6362 mL 5.2725 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.67%

SDS (251 KB)

COA (249 KB) HNMR (254 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

  • [1].

  • [1].

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6362 mL 13.1811 mL 26.3623 mL 65.9057 mL
5 mM 0.5272 mL 2.6362 mL 5.2725 mL 13.1811 mL
10 mM 0.2636 mL 1.3181 mL 2.6362 mL 6.5906 mL
15 mM 0.1757 mL 0.8787 mL 1.7575 mL 4.3937 mL
20 mM 0.1318 mL 0.6591 mL 1.3181 mL 3.2953 mL
25 mM 0.1054 mL 0.5272 mL 1.0545 mL 2.6362 mL
30 mM 0.0879 mL 0.4394 mL 0.8787 mL 2.1969 mL
40 mM 0.0659 mL 0.3295 mL 0.6591 mL 1.6476 mL
50 mM 0.0527 mL 0.2636 mL 0.5272 mL 1.3181 mL
60 mM 0.0439 mL 0.2197 mL 0.4394 mL 1.0984 mL
80 mM 0.0330 mL 0.1648 mL 0.3295 mL 0.8238 mL
100 mM 0.0264 mL 0.1318 mL 0.2636 mL 0.6591 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

AZD4144 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZD41442890191-41-8AZD 4144AZD-4144NOD-like Receptor (NLR)orally activeNLRP3Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
AZD4144
Cat. No.:
HY-162877
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.