2. Apoptosis
  3. Apoptosis
  4. B-355252

B355252, a phenoxy thiophene sulfonamide small molecule, is a potent NGF receptor agonist. B355252 potentiates NGF-induced neurite outgrowth. B355252 protects ischemic neurons from neuronal loss by attenuating DNA damage, reducing ROS production and the LDH level, and preventing neuronal apoptosis. B355252 has anti-apoptotic effects in glutamate-induced excitotoxicity, as well as in a murine hippocampal cell line (HT22) model of Parkinson disease (PD).

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B-355252 Chemical Structure

B-355252 Chemical Structure

CAS No. : 1261576-81-1

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Description

B355252, a phenoxy thiophene sulfonamide small molecule, is a potent NGF receptor agonist. B355252 potentiates NGF-induced neurite outgrowth. B355252 protects ischemic neurons from neuronal loss by attenuating DNA damage, reducing ROS production and the LDH level, and preventing neuronal apoptosis. B355252 has anti-apoptotic effects in glutamate-induced excitotoxicity, as well as in a murine hippocampal cell line (HT22) model of Parkinson disease (PD)[1].

In Vivo

B-355252 (0.125 mg/kg; ip; daily; 3 days) significantly attenuates the infarct volume and protects post-stroke neuronal loss in adult male Sprague–Dawley rats with cerebral ischemia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

514.06

Formula

C25H24ClN3O3S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC(Cl)=C(S1)OC2=CC=CC(N3CCNCC3)=C2)(NCC4=C5C=CC=CC5=CC=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (58.36 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9453 mL 9.7265 mL 19.4530 mL
5 mM 0.3891 mL 1.9453 mL 3.8906 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

SDS (420 KB)

COA (254 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9453 mL 9.7265 mL 19.4530 mL 48.6325 mL
5 mM 0.3891 mL 1.9453 mL 3.8906 mL 9.7265 mL
10 mM 0.1945 mL 0.9726 mL 1.9453 mL 4.8632 mL
15 mM 0.1297 mL 0.6484 mL 1.2969 mL 3.2422 mL
20 mM 0.0973 mL 0.4863 mL 0.9726 mL 2.4316 mL
25 mM 0.0778 mL 0.3891 mL 0.7781 mL 1.9453 mL
30 mM 0.0648 mL 0.3242 mL 0.6484 mL 1.6211 mL
40 mM 0.0486 mL 0.2432 mL 0.4863 mL 1.2158 mL
50 mM 0.0389 mL 0.1945 mL 0.3891 mL 0.9726 mL
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B-355252 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

B-3552521261576-81-1B355252B 355252Apoptosisphenoxy thiophene sulfonamideNGFneurite outgrowthischemic neuronsDNA damageROS productionLDH levelglutamateHT22 Parkinson diseaseInhibitorinhibitorinhibit

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