2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. Basroparib

Basroparib  (Synonyms: STP1002)

Cat. No.: HY-147245 Purity: 98.49%
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Basroparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor with an IC50 of 5.8 nM for TNKS1, exhibiting antitumor activity.

For research use only. We do not sell to patients.

Basroparib Chemical Structure

Basroparib Chemical Structure

CAS No. : 1858179-75-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 379 In-stock
Solution
10 mM * 1 mL in DMSO USD 379 In-stock
Solid
5 mg USD 345 In-stock
10 mg USD 555 In-stock
25 mg USD 1110 In-stock
50 mg USD 1885 In-stock
100 mg USD 3200 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Basroparib Related Antibodies

Top Publications Citing Use of Products

View All PARP Isoform Specific Products:

View All Isoforms
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

Basroparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor with an IC50 of 5.8 nM for TNKS1, exhibiting antitumor activity[1][2].

IC50 & Target

PARP[1]
Clinical Trial
Molecular Weight

421.40

Formula

C18H21F2N7O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1N=C(N2CCN(CC2)C3=C(C=C(C=C3F)OCCOC)F)NC4=C1N=NN4C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (237.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3730 mL 11.8652 mL 23.7304 mL
5 mM 0.4746 mL 2.3730 mL 4.7461 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3730 mL 11.8652 mL 23.7304 mL 59.3261 mL
5 mM 0.4746 mL 2.3730 mL 4.7461 mL 11.8652 mL
10 mM 0.2373 mL 1.1865 mL 2.3730 mL 5.9326 mL
15 mM 0.1582 mL 0.7910 mL 1.5820 mL 3.9551 mL
20 mM 0.1187 mL 0.5933 mL 1.1865 mL 2.9663 mL
25 mM 0.0949 mL 0.4746 mL 0.9492 mL 2.3730 mL
30 mM 0.0791 mL 0.3955 mL 0.7910 mL 1.9775 mL
40 mM 0.0593 mL 0.2966 mL 0.5933 mL 1.4832 mL
50 mM 0.0475 mL 0.2373 mL 0.4746 mL 1.1865 mL
60 mM 0.0396 mL 0.1978 mL 0.3955 mL 0.9888 mL
80 mM 0.0297 mL 0.1483 mL 0.2966 mL 0.7416 mL
100 mM 0.0237 mL 0.1187 mL 0.2373 mL 0.5933 mL
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Basroparib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Basroparib1858179-75-5STP1002STP 1002STP-1002PARPpoly ADP ribose polymeraseantineoplasticInhibitorinhibitorinhibit

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