2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. BAY-4931

BAY-4931 is a potent, covalent and selective PPARγ inverse-agonist with an IC50 of 0.17 nM.

For research use only. We do not sell to patients.

BAY-4931 Chemical Structure

BAY-4931 Chemical Structure

CAS No. : 423150-91-8

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Based on 1 publication(s) in Google Scholar

BAY-4931 Related Antibodies

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View All PPAR Isoform Specific Products:

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PPARα PPARβ/δ PPARγ PPAR PPARδ

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  • Purity & Documentation

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Description

BAY-4931 is a potent, covalent and selective PPARγ inverse-agonist with an IC50 of 0.17 nM[1].

IC50 & Target[1]

PPAR-γ

0.17 nM (IC50, RT112-FABP4-NLucP cellular reporter assay)

mouse PPARγ

0.14 nM (IC50, GAL4-NHR-LBD one hybrid reporter assay )

hPPARγ

0.40 nM (IC50, GAL4-NHR-LBD one hybrid reporter assay )

In Vitro

BAY-4931 (0-10 μM; 7 days) inhibits UM-UC-9 proliferation with an IC50 of 3.4 nM[1].
BAY-4931 only inhibits CYP2C8 in CYP inhibition test[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BAY-4931 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: UM-UC-9 cells
Concentration: 0-10 μM
Incubation Time: 7 days
Result: Inhibited proliferation with an IC50 of 3.4 nM.
Molecular Weight

421.83

Formula

C22H16ClN3O4
CAS No.
Appearance

Solid

Color

Light yellow to light brown

SMILES

O=C(NC1=CC=C(OC(C2=CC=C(CC)C=C2)=N3)C3=C1)C4=CC([N+]([O-])=O)=CC=C4Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (296.33 mM; ultrasonic and warming and heat to 70°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3706 mL 11.8531 mL 23.7062 mL
5 mM 0.4741 mL 2.3706 mL 4.7412 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3706 mL 11.8531 mL 23.7062 mL 59.2656 mL
5 mM 0.4741 mL 2.3706 mL 4.7412 mL 11.8531 mL
10 mM 0.2371 mL 1.1853 mL 2.3706 mL 5.9266 mL
15 mM 0.1580 mL 0.7902 mL 1.5804 mL 3.9510 mL
20 mM 0.1185 mL 0.5927 mL 1.1853 mL 2.9633 mL
25 mM 0.0948 mL 0.4741 mL 0.9482 mL 2.3706 mL
30 mM 0.0790 mL 0.3951 mL 0.7902 mL 1.9755 mL
40 mM 0.0593 mL 0.2963 mL 0.5927 mL 1.4816 mL
50 mM 0.0474 mL 0.2371 mL 0.4741 mL 1.1853 mL
60 mM 0.0395 mL 0.1976 mL 0.3951 mL 0.9878 mL
80 mM 0.0296 mL 0.1482 mL 0.2963 mL 0.7408 mL
100 mM 0.0237 mL 0.1185 mL 0.2371 mL 0.5927 mL
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BAY-4931 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY-4931423150-91-8BAY4931BAY 4931PPARPeroxisome proliferator-activated receptorsUM-UC-9CYP2C8Inhibitorinhibitorinhibit

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