2. Apoptosis Protein Tyrosine Kinase/RTK
  3. Apoptosis Syk
  4. BAY 61-3606 hydrochloride

BAY 61-3606 hydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM and an IC50 of 10 nM . BAY 61-3606 hydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell. BAY 61-3606 hydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates. BAY 61-3606 hydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.

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BAY 61-3606 hydrochloride Chemical Structure

BAY 61-3606 hydrochloride Chemical Structure

CAS No. : 1615197-10-8

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1 mg USD 66 In-stock
5 mg USD 165 In-stock
10 mg USD 280 In-stock
25 mg USD 550 In-stock
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Based on 8 publication(s) in Google Scholar

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Description

BAY 61-3606 hydrochloride is an orally available, ATP-competitive, reversible and highly selective Syk inhibitor with a Ki of 7.5 nM and an IC50 of 10 nM . BAY 61-3606 hydrochloride reduces ERK1/2 and Akt phosphorylation in neuroblastoma cell. BAY 61-3606 hydrochloride induces a large decrease of Syk phosphorylation in K-rn cell lysates. BAY 61-3606 hydrochloride sensitizes TRAIL-induced apoptosis by downregulating Mcl-1 in breast cancer cells.

Molecular Weight

426.86

Formula

C20H19ClN6O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

NC(C1=C(N=CC=C1)NC2=NC(C3=CC(OC)=C(C=C3)OC)=CC4=NC=CN24)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (58.57 mM; ultrasonic and warming and heat to 160°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3427 mL 11.7134 mL 23.4269 mL
5 mM 0.4685 mL 2.3427 mL 4.6854 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3427 mL 11.7134 mL 23.4269 mL 58.5672 mL
5 mM 0.4685 mL 2.3427 mL 4.6854 mL 11.7134 mL
10 mM 0.2343 mL 1.1713 mL 2.3427 mL 5.8567 mL
15 mM 0.1562 mL 0.7809 mL 1.5618 mL 3.9045 mL
20 mM 0.1171 mL 0.5857 mL 1.1713 mL 2.9284 mL
25 mM 0.0937 mL 0.4685 mL 0.9371 mL 2.3427 mL
30 mM 0.0781 mL 0.3904 mL 0.7809 mL 1.9522 mL
40 mM 0.0586 mL 0.2928 mL 0.5857 mL 1.4642 mL
50 mM 0.0469 mL 0.2343 mL 0.4685 mL 1.1713 mL
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BAY 61-3606 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY 61-36061615197-10-8ApoptosisSykSpleen tyrosine kinaseInhibitorinhibitorinhibit

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