BCL6-IN-6

Cat. No.: HY-143653 Purity: 98.39%: FAQs
Data Sheet SDS COA Handling Instructions

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BCL6-IN-6 is a potent inhibitor of transcriptional repressor B-cell lymphoma 6 (BCL6). BCL6-IN-6 significantly blocks the interaction of BCL6 with its corepressors and reactivates BCL6 target genes in a dose-dependent manner. BCL6-IN-6 has the potential for the research of diffuse large B-cell lymphoma (DLBCL).

For research use only. We do not sell to patients.

BCL6-IN-6 Chemical Structure

CAS No. : 2408882-54-0

Size	Price	Stock	Quantity
5 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 460	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 820	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1300	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2000	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

BCL6^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
DOHH-2	IC₅₀	1 μM Compound: 28	Antiproliferative activity against BCL-6 dependent human DOHH-2 cells by CCK-8 assay Antiproliferative activity against BCL-6 dependent human DOHH-2 cells by CCK-8 assay	[PMID: 33844535]
DOHH-2	IC₅₀	1.21 μM Compound: 14j	Antiproliferative activity against human DOHH2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against human DOHH2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 31895575]
Farage	IC₅₀	1 μM Compound: 28	Antiproliferative activity against BCL-6 dependent human Farage cells by CCK-8 assay Antiproliferative activity against BCL-6 dependent human Farage cells by CCK-8 assay	[PMID: 33844535]
Farage	IC₅₀	1.26 μM Compound: 14j	Antiproliferative activity against human Farage cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against human Farage cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 31895575]
L02	IC₅₀	13.1 μM Compound: 14j	Cytotoxicity against human LO2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Cytotoxicity against human LO2 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 31895575]
NCM460	IC₅₀	32.4 μM Compound: 14j	Cytotoxicity against human NCM460 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Cytotoxicity against human NCM460 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 31895575]
OCI-Ly7	IC₅₀	1 μM Compound: 28	Antiproliferative activity against BCL-6 dependent human OCILY7 cells by CCK-8 assay Antiproliferative activity against BCL-6 dependent human OCILY7 cells by CCK-8 assay	[PMID: 33844535]
OCI-Ly7	IC₅₀	1.62 μM Compound: 14j	Antiproliferative activity against human OCI-LY7 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against human OCI-LY7 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 31895575]
PNT1A	IC₅₀	8.13 μM Compound: 14j	Cytotoxicity against human PNT1A cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Cytotoxicity against human PNT1A cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 31895575]
SUD4	IC₅₀	0.92 μM Compound: 14j	Antiproliferative activity against human SUDHL4 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against human SUDHL4 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 31895575]
SUD4	IC₅₀	1 μM Compound: 28	Antiproliferative activity against BCL-6 dependent human SU-DHL-4 cells by CCK-8 assay Antiproliferative activity against BCL-6 dependent human SU-DHL-4 cells by CCK-8 assay	[PMID: 33844535]
Toledo	IC₅₀	3.25 μM Compound: 14j	Antiproliferative activity against BCL6-negative human Toledo cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against BCL6-negative human Toledo cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 31895575]
Toledo	IC₅₀	3.3 μM Compound: 28	Antiproliferative activity against BCL-6 independent human Toledo cells by CCK-8 assay Antiproliferative activity against BCL-6 independent human Toledo cells by CCK-8 assay	[PMID: 33844535]

Molecular Weight

522.64

Formula

C₂₇H₃₁FN₆O₂S

CAS No.

2408882-54-0

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC=C(C2=CCCC2)S1)NC3=CC=C(NC4=NC(N5C[C@@H](C)N[C@@H](C)C5)=NC=C4F)C=C3OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 4 mg/mL (7.65 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9134 mL	9.5668 mL	19.1336 mL
5 mM	0.3827 mL	1.9134 mL	3.8267 mL
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.39%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (248 KB) HNMR (314 KB) LCMS (261 KB)

Handling Instructions (2659 KB)

References

[1]. Guo W, et al. Synthesis and Biological Evaluation of B-Cell Lymphoma 6 Inhibitors of N-Phenyl-4-pyrimidinamine Derivatives Bearing Potent Activities against Tumor Growth. J Med Chem. 2020;63(2):676-695. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9134 mL	9.5668 mL	19.1336 mL	47.8341 mL
DMSO	5 mM	0.3827 mL	1.9134 mL	3.8267 mL	9.5668 mL

BCL6-IN-6 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BCL6-IN-62408882-54-0BCL6B-cell lymphoma 6 proteinB-cell lymphoma 5 protein (BCL-5)Zinc finger and BTB domain-containing protein 27Zinc finger protein 51corepressorsDLBCLInhibitorinhibitorinhibit

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BCL6-IN-6

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BCL6-IN-6 Related Antibodies

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Complete Stock Solution Preparation Table

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