Belotecan-d₇ hydrochloride

Name: Belotecan-d 7 hydrochloride
Brand: MedChemExpress
SKU: HY-13566AS
Rating: 4.5 (1 reviews)

Cat. No.: HY-13566AS Purity: ≥96.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Belotecan-d₇ (hydrochloride) is the deuterium labeled Belotecan hydrochloride. Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative[1][2].

For research use only. We do not sell to patients.

Belotecan-d<sub>7</sub> hydrochloride Chemical Structure

Belotecan-d₇ hydrochloride Chemical Structure

CAS No. : 1346598-22-8

Size	Price	Stock	Quantity
1 mg	USD 470	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1400	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Belotecan-d₇ hydrochloride:

Belotecan hydrochloride In-stock

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•Related Small Molecules:

•Related Proteins:

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Topoisomerase Topo I Topo II

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

477.00

Formula

C₂₅H₂₁D₇ClN₃O₄

CAS No.

1346598-22-8

Unlabeled CAS

213819-48-8

Appearance

Solid

Color

White to off-white

SMILES

O=C1N2C(C3=NC4=CC=CC=C4C(CCNC(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=C3C2)=CC5=C1COC([C@]5(O)CC)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 12.5 mg/mL (26.21 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0964 mL	10.4822 mL	20.9644 mL
5 mM	0.4193 mL	2.0964 mL	4.1929 mL
10 mM	0.2096 mL	1.0482 mL	2.0964 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 96.00%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (257 KB) Elemental Analysis Report (116 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Kim YK, et al. Anticancer effects of CKD-602 (Camtobell?) via G2/M phase arrest in oral squamous cell carcinoma cell lines. Oncol Lett. 2015 Jan;9(1):136-142. [Content Brief]

[3]. Kim YY, et al. CKD-602, a camptothecin derivative, inhibits proliferation and induces apoptosis in glioma cell lines. Oncol Rep. 2009 Jun;21(6):1413-9. [Content Brief]

[4]. Kim CY, et al. Antitumor activity of CKD-602, a camptothecin derivative, in a mouse glioma model. J Clin Neurosci. 2012 Feb;19(2):301-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO	1 mM	2.0964 mL	10.4822 mL	20.9644 mL	52.4109 mL
	5 mM	0.4193 mL	2.0964 mL	4.1929 mL	10.4822 mL
	10 mM	0.2096 mL	1.0482 mL	2.0964 mL	5.2411 mL
	15 mM	0.1398 mL	0.6988 mL	1.3976 mL	3.4941 mL
	20 mM	0.1048 mL	0.5241 mL	1.0482 mL	2.6205 mL
	25 mM	0.0839 mL	0.4193 mL	0.8386 mL	2.0964 mL