2. Antibody-drug Conjugate/ADC Related
  3. ADC Cytotoxin
  4. Benzyl DC-81

Benzyl DC-81 (Compound 6a) is an anticancer agent with antiproliferative activity against A375 and MCF-7 cells.

For research use only. We do not sell to patients.

Benzyl DC-81 Chemical Structure

Benzyl DC-81 Chemical Structure

CAS No. : 127810-79-1

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Based on 1 publication(s) in Google Scholar

Benzyl DC-81 Related Antibodies

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Description

Benzyl DC-81 (Compound 6a) is an anticancer agent with antiproliferative activity against A375 and MCF-7 cells[1].

Molecular Weight

336.38

Formula

C20H20N2O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=CC(OC)=C(OCC3=CC=CC=C3)C=C2N=C[C@@]4([H])N1CCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 300 mg/mL (891.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9728 mL 14.8641 mL 29.7283 mL
5 mM 0.5946 mL 2.9728 mL 5.9457 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9728 mL 14.8641 mL 29.7283 mL 74.3207 mL
5 mM 0.5946 mL 2.9728 mL 5.9457 mL 14.8641 mL
10 mM 0.2973 mL 1.4864 mL 2.9728 mL 7.4321 mL
15 mM 0.1982 mL 0.9909 mL 1.9819 mL 4.9547 mL
20 mM 0.1486 mL 0.7432 mL 1.4864 mL 3.7160 mL
25 mM 0.1189 mL 0.5946 mL 1.1891 mL 2.9728 mL
30 mM 0.0991 mL 0.4955 mL 0.9909 mL 2.4774 mL
40 mM 0.0743 mL 0.3716 mL 0.7432 mL 1.8580 mL
50 mM 0.0595 mL 0.2973 mL 0.5946 mL 1.4864 mL
60 mM 0.0495 mL 0.2477 mL 0.4955 mL 1.2387 mL
80 mM 0.0372 mL 0.1858 mL 0.3716 mL 0.9290 mL
100 mM 0.0297 mL 0.1486 mL 0.2973 mL 0.7432 mL
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Benzyl DC-81 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Benzyl DC-81127810-79-1Benzyl DC81Benzyl DC 81ADC CytotoxinADC PayloadInhibitorinhibitorinhibit

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