Benzyl nicotinate

Name: Benzyl nicotinate
Brand: MedChemExpress
SKU: HY-B1555
Rating: 4.5 (1 reviews)

Cat. No.: HY-B1555 Purity: 97.29%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Benzyl nicotinate is a vasodilator that increases skin oxygenation levels by increasing skin blood flow.

For research use only. We do not sell to patients.

Benzyl nicotinate Chemical Structure

CAS No. : 94-44-0

Size	Stock	Quantity

Free Sample (0.1 - 0.5 mg)	Apply Now
Solid or liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid or liquid
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
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50 g	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Benzyl nicotinate:

Benzyl nicotinate (Standard) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Benzyl nicotinate is a vasodilator that increases skin oxygenation levels by increasing skin blood flow^[1]^[2].

In Vitro

Benzyl nicotinate crosses the skin, releases nicotinic acid by enzymatic hydrolysis, increases local cutaneous blood flow, and promotes skin oxygenation. Benzyl nicotinate can be used for for particulate encapsulation, skin penetration and detection for its lipophilicity^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Benzyl nicotinate (2.5% w/w, topical administration to the skin, single dose) affects the lipid structure, increases the lipid fluidity in the stratum corneum, exhibits good skin oxygenation levels in BALB/c mouse models^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c mouse models^[3]
Dosage:	2.5% w/w
Administration:	topical administration to the skin, single dose
Result:	Increased the lipid fluidity in the stratum corneum.

Molecular Weight

213.24

Formula

C₁₃H₁₁NO₂

CAS No.

94-44-0

Appearance

<24°C Solid,>24°C Liquid

Color

Colorless to light yellow

SMILES

O=C(C1=CC=CN=C1)OCC2=CC=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (468.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.6896 mL	23.4482 mL	46.8964 mL
5 mM	0.9379 mL	4.6896 mL	9.3793 mL
10 mM	0.4690 mL	2.3448 mL	4.6896 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.60%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (246 KB) HNMR (117 KB) RP-HPLC (341 KB)

Handling Instructions (2659 KB)

References

[1]. Erjavec V, et al. In vivo study of liposomes as drug carriers to oral mucosa using EPR oximetry. Int J Pharm. 2006;307(1):1-8. [Content Brief]

[2]. Petelin M, et al. In vivo study of different ointments for drug delivery into oral mucosa by EPR oximetry. Int J Pharm. 2004;270(1-2):83-91. [Content Brief]

[3]. Abramović Z, et al., Influence of nanosized delivery systems with benzyl nicotinate and penetration enhancers on skin oxygenation. Int J Pharm. 2008 Jul 9;359(1-2):220-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.6896 mL	23.4482 mL	46.8964 mL	117.2410 mL
	5 mM	0.9379 mL	4.6896 mL	9.3793 mL	23.4482 mL
	10 mM	0.4690 mL	2.3448 mL	4.6896 mL	11.7241 mL
	15 mM	0.3126 mL	1.5632 mL	3.1264 mL	7.8161 mL
	20 mM	0.2345 mL	1.1724 mL	2.3448 mL	5.8620 mL
	25 mM	0.1876 mL	0.9379 mL	1.8759 mL	4.6896 mL
	30 mM	0.1563 mL	0.7816 mL	1.5632 mL	3.9080 mL
	40 mM	0.1172 mL	0.5862 mL	1.1724 mL	2.9310 mL
	50 mM	0.0938 mL	0.4690 mL	0.9379 mL	2.3448 mL
	60 mM	0.0782 mL	0.3908 mL	0.7816 mL	1.9540 mL
	80 mM	0.0586 mL	0.2931 mL	0.5862 mL	1.4655 mL
	100 mM	0.0469 mL	0.2345 mL	0.4690 mL	1.1724 mL