2. Metabolic Enzyme/Protease
  3. 11β-HSD
  4. BI 187004

BI 187004 (VTP-34072) is an 11β-hydroxysteroid dehydrogenase 1 inhibitor for use in diabetes research.

For research use only. We do not sell to patients.

BI 187004 Chemical Structure

BI 187004 Chemical Structure

CAS No. : 1303515-32-3

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Description

BI 187004 (VTP-34072) is an 11β-hydroxysteroid dehydrogenase 1 inhibitor for use in diabetes research[1].

Molecular Weight

342.39

Formula

C21H18N4O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CC1=CC2=C(C=C1)C[C@@]3([H])[C@]2([H])CCCN3C(C4=CC=C5N=CNC5=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (365.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9206 mL 14.6032 mL 29.2065 mL
5 mM 0.5841 mL 2.9206 mL 5.8413 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9206 mL 14.6032 mL 29.2065 mL 73.0161 mL
5 mM 0.5841 mL 2.9206 mL 5.8413 mL 14.6032 mL
10 mM 0.2921 mL 1.4603 mL 2.9206 mL 7.3016 mL
15 mM 0.1947 mL 0.9735 mL 1.9471 mL 4.8677 mL
20 mM 0.1460 mL 0.7302 mL 1.4603 mL 3.6508 mL
25 mM 0.1168 mL 0.5841 mL 1.1683 mL 2.9206 mL
30 mM 0.0974 mL 0.4868 mL 0.9735 mL 2.4339 mL
40 mM 0.0730 mL 0.3651 mL 0.7302 mL 1.8254 mL
50 mM 0.0584 mL 0.2921 mL 0.5841 mL 1.4603 mL
60 mM 0.0487 mL 0.2434 mL 0.4868 mL 1.2169 mL
80 mM 0.0365 mL 0.1825 mL 0.3651 mL 0.9127 mL
100 mM 0.0292 mL 0.1460 mL 0.2921 mL 0.7302 mL
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BI 187004 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BI 1870041303515-32-3VTP-34072BI187004BI-187004VTP34072VTP 3407211β-HSD11beta-HSD11β-hydroxysteroid dehydrogenases11 beta-hydroxysteroid dehydrogenase11β-HSD inhibitorInhibitorinhibitorinhibit

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