2. Metabolic Enzyme/Protease Anti-infection
  3. HIV Integrase HIV
  4. Bictegravir sodium

Bictegravir sodium  (Synonyms: GS-9883 sodium)

Cat. No.: HY-17605A Purity: 99.71%
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Bictegravir sodium is a potent inhibitor of HIV-1 integrase, with an IC50 of 7.5 nM. Bictegravir sodium exhibits potent and selective anti-HIV activity and low cytotoxicity.

For research use only. We do not sell to patients.

Bictegravir sodium Chemical Structure

Bictegravir sodium Chemical Structure

CAS No. : 1807988-02-8

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1 mg USD 55 In-stock
5 mg USD 77 In-stock
10 mg USD 132 In-stock
25 mg USD 267 In-stock
50 mg USD 462 In-stock
100 mg USD 825 In-stock
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Based on 10 publication(s) in Google Scholar

Other Forms of Bictegravir sodium:

Bictegravir sodium Related Antibodies

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Description

Bictegravir sodium is a potent inhibitor of HIV-1 integrase, with an IC50 of 7.5 nM. Bictegravir sodium exhibits potent and selective anti-HIV activity and low cytotoxicity[1].

IC50 & Target

HIV-1

 

In Vitro

Bictegravir sodium potently inhibits HIV-1 replication in both MT-2 and MT-4 cells with EC50s of 1.5 and 2.4 nM, respectively, and selectivity indices (50% cytotoxic concentration [CC50]/EC50) of ∼6,800 in MT-2 cells and ∼1,500 in MT-4 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bictegravir sodium Related Antibodies
Clinical Trial
Molecular Weight

471.36

Formula

C21H17F3N3NaO5
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1N([C@](CC2)([H])C[C@]2([H])O3)[C@@]3([H])CN(C=C(C(NCC(C(F)=CC(F)=C4)=C4F)=O)C5=O)C1=C5O[Na]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (35.37 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1215 mL 10.6076 mL 21.2152 mL
5 mM 0.4243 mL 2.1215 mL 4.2430 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1215 mL 10.6076 mL 21.2152 mL 53.0380 mL
5 mM 0.4243 mL 2.1215 mL 4.2430 mL 10.6076 mL
10 mM 0.2122 mL 1.0608 mL 2.1215 mL 5.3038 mL
15 mM 0.1414 mL 0.7072 mL 1.4143 mL 3.5359 mL
20 mM 0.1061 mL 0.5304 mL 1.0608 mL 2.6519 mL
25 mM 0.0849 mL 0.4243 mL 0.8486 mL 2.1215 mL
30 mM 0.0707 mL 0.3536 mL 0.7072 mL 1.7679 mL
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Bictegravir sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bictegravir1807988-02-8GS-9883GS9883GS 9883HIV IntegraseHIVHuman immunodeficiency virusMT-2 cellsMT-4 cells293T cellsanti-HIVlow cytotoxicityInhibitorinhibitorinhibit

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