Bis-PEG9-acid

Cat. No.: HY-126894: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Bis- PEG9- acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis- PEG9- acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

Bis-PEG9-acid Chemical Structure

CAS No. : 1268488-70-5

Size	Price	Stock
25 mg	USD 26	Ask For Quote & Lead Time
50 mg	USD 40	Ask For Quote & Lead Time
100 mg	USD 61	Ask For Quote & Lead Time
250 mg	USD 102	Ask For Quote & Lead Time

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Bis- PEG9- acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis- PEG9- acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

IC₅₀ & Target^[1]

PEGs	Cleavable Linker

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

514.56

Formula

C₂₂H₄₂O₁₃

CAS No.

1268488-70-5

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (267 KB) SDS (393 KB)

COA (247 KB) HNMR (131 KB)

Handling Instructions (2659 KB)

References

[1]. Bach A, et al. Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDAreceptor interaction. Angew Chem Int Ed Engl. 2009;48(51):9685-9. [Content Brief]

[2]. Norbert Basler, et al. Nucleoside-triphosphate conjugate and methods for the use thereof. WO2012150035A1.

Bis-PEG9-acid Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bis-PEG9-acid1268488-70-5PROTAC LinkersADC LinkerAntibody-drug conjugates linkerPEGPROTAClinkerE3ubiquitinligaseproteincleavableADCantibody-drugconjugatesInhibitorinhibitorinhibit

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