2. PROTAC
  3. PROTAC Linkers
  4. DBCO-PEG3-NHS

DBCO-PEG3-NHS is a biochemical assay reagent, that can be used to chemically modify proteins and antibodies with an alkynyl (DBCO) or N-hydroxysuccinimide (NHS) ester group. DBCO-PEG3-NHS can be used as a linker in PROTAC synthesis or for drug delivery and the development of biosensors and diagnostic reagents.

For research use only. We do not sell to patients.

DBCO-PEG3-NHS Chemical Structure

DBCO-PEG3-NHS Chemical Structure

CAS No. : 2249926-63-2

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Description

DBCO-PEG3-NHS is a biochemical assay reagent, that can be used to chemically modify proteins and antibodies with an alkynyl (DBCO) or N-hydroxysuccinimide (NHS) ester group. DBCO-PEG3-NHS can be used as a linker in PROTAC synthesis or for drug delivery and the development of biosensors and diagnostic reagents[1].

Molecular Weight

591.61

Formula

C31H33N3O9
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(COCCOCCOCCNC(CCC(N1C2=C(C#CC3=C(C1)C=CC=C3)C=CC=C2)=O)=O)ON4C(CCC4=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (84.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6903 mL 8.4515 mL 16.9030 mL
5 mM 0.3381 mL 1.6903 mL 3.3806 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6903 mL 8.4515 mL 16.9030 mL 42.2576 mL
5 mM 0.3381 mL 1.6903 mL 3.3806 mL 8.4515 mL
10 mM 0.1690 mL 0.8452 mL 1.6903 mL 4.2258 mL
15 mM 0.1127 mL 0.5634 mL 1.1269 mL 2.8172 mL
20 mM 0.0845 mL 0.4226 mL 0.8452 mL 2.1129 mL
25 mM 0.0676 mL 0.3381 mL 0.6761 mL 1.6903 mL
30 mM 0.0563 mL 0.2817 mL 0.5634 mL 1.4086 mL
40 mM 0.0423 mL 0.2113 mL 0.4226 mL 1.0564 mL
50 mM 0.0338 mL 0.1690 mL 0.3381 mL 0.8452 mL
60 mM 0.0282 mL 0.1409 mL 0.2817 mL 0.7043 mL
80 mM 0.0211 mL 0.1056 mL 0.2113 mL 0.5282 mL
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DBCO-PEG3-NHS Related Classifications

Keywords:

DBCO-PEG3-NHS2249926-63-2PROTAC LinkersInhibitorinhibitorinhibit

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