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  4. BMS-566419

BMS-566419 is an acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase (IMPDH). Inosine monophosphate dehydrogenase (IMPDH) is a key enzyme in the de novo synthesis of guanosine nucleotides. BMS-566419 has clinical utility for the research of transplant rejection.

For research use only. We do not sell to patients.

BMS-566419 Chemical Structure

BMS-566419 Chemical Structure

CAS No. : 566161-24-8

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1 mg USD 148 In-stock
5 mg USD 371 In-stock
10 mg USD 593 In-stock
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Description

BMS-566419 is an acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase (IMPDH). Inosine monophosphate dehydrogenase (IMPDH) is a key enzyme in the de novo synthesis of guanosine nucleotides. BMS-566419 has clinical utility for the research of transplant rejection[1].

Molecular Weight

487.57

Formula

C28H30FN5O2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=CC(F)=C(C(NC(C)(C3=CN=C(N4CCN(CC)CC4)C=C3)C)=O)C=C2NC5=CC=CC=C15
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (25.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0510 mL 10.2549 mL 20.5099 mL
5 mM 0.4102 mL 2.0510 mL 4.1020 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.68%

COA (246 KB) HNMR (138 KB) RP-HPLC (145 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0510 mL 10.2549 mL 20.5099 mL 51.2747 mL
5 mM 0.4102 mL 2.0510 mL 4.1020 mL 10.2549 mL
10 mM 0.2051 mL 1.0255 mL 2.0510 mL 5.1275 mL
15 mM 0.1367 mL 0.6837 mL 1.3673 mL 3.4183 mL
20 mM 0.1025 mL 0.5127 mL 1.0255 mL 2.5637 mL
25 mM 0.0820 mL 0.4102 mL 0.8204 mL 2.0510 mL
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BMS-566419 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-566419566161-24-8BMS566419BMS 566419OthersIMPDHacridone-basedguanosine nucleotidestransplant rejectionInhibitorinhibitorinhibit

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