2. Metabolic Enzyme/Protease
  3. 11β-HSD
  4. BMS-770767

BMS-770767 is an 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor in type 2 diabetes. 11β-HSD1 is an important enzyme that is widely expressed in liver, adipose tissue and other tissues and plays an important role in metabolic diseases such as diabetes and obesity.

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BMS-770767 Chemical Structure

BMS-770767 Chemical Structure

CAS No. : 1875067-34-7

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5 mg USD 530 In-stock
10 mg USD 855 In-stock
25 mg USD 1715 In-stock
50 mg USD 2750 In-stock
100 mg USD 4400 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

BMS-770767 is an 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor in type 2 diabetes. 11β-HSD1 is an important enzyme that is widely expressed in liver, adipose tissue and other tissues and plays an important role in metabolic diseases such as diabetes and obesity[1].

Molecular Weight

355.82

Formula

C19H18ClN3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC12CC(CC2)(C3=NN=C4N3C=CC=C4OC5=C(C=CC=C5)Cl)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (281.04 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8104 mL 14.0520 mL 28.1041 mL
5 mM 0.5621 mL 2.8104 mL 5.6208 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8104 mL 14.0520 mL 28.1041 mL 70.2602 mL
5 mM 0.5621 mL 2.8104 mL 5.6208 mL 14.0520 mL
10 mM 0.2810 mL 1.4052 mL 2.8104 mL 7.0260 mL
15 mM 0.1874 mL 0.9368 mL 1.8736 mL 4.6840 mL
20 mM 0.1405 mL 0.7026 mL 1.4052 mL 3.5130 mL
25 mM 0.1124 mL 0.5621 mL 1.1242 mL 2.8104 mL
30 mM 0.0937 mL 0.4684 mL 0.9368 mL 2.3420 mL
40 mM 0.0703 mL 0.3513 mL 0.7026 mL 1.7565 mL
50 mM 0.0562 mL 0.2810 mL 0.5621 mL 1.4052 mL
60 mM 0.0468 mL 0.2342 mL 0.4684 mL 1.1710 mL
80 mM 0.0351 mL 0.1757 mL 0.3513 mL 0.8783 mL
100 mM 0.0281 mL 0.1405 mL 0.2810 mL 0.7026 mL
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BMS-770767 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-7707671875067-34-7BMS770767BMS 77076711β-HSD11beta-HSD11β-hydroxysteroid dehydrogenases11 beta-hydroxysteroid dehydrogenaseInhibitorinhibitorinhibit

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