2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. BMS-986189

BMS-986189 is a macrocyclic peptide PD-1/PD-L1 interaction with an IC50 of 1.03 nM inhibitor. BMS-986189 can be used for cancer research, such as human lung carcinoma cells L2987.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

BMS-986189 Chemical Structure

BMS-986189 Chemical Structure

CAS No. : 1629665-96-8

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Based on 1 publication(s) in Google Scholar

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Description

BMS-986189 is a macrocyclic peptide PD-1/PD-L1 interaction with an IC50 of 1.03 nM inhibitor. BMS-986189 can be used for cancer research, such as human lung carcinoma cells L2987[1][2].

In Vivo

BMS-986189 (2 mg/kg; subcutaneous administration; one dose) inhibits the signal within the L2987 xenograft. BMS-986189 could maintain PD-L1 target engagement over a 24-h period within PD-L1-positive tissues[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5-6-week-old female athymic nude mice were established by subcutaneous inoculation of HT-29 and L2987 in contralateral shoulders in a total injection volume of 0.2 mL[2].
Dosage: 2 mg/kg
Administration: Subcutaneous administration; one dose
Result: A 94% reduction of the signal within the L2987 xenograft was observed when compared to the radiotracer alone.
Molecular Weight

1887.21

Formula

C91H131N21O21S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ac-Tyr-{NMe-Ala}-Asn-Pro-Dap-Leu-Hyp-Trp-Dab-Trp{CH2COOH}-{NMe-Nle}-(NMe-Nle)-Leu-Cys-Gly-NH2 (thioether bridge:Tyr1-Cys14)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (52.99 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : ≥ 1 mg/mL (0.53 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5299 mL 2.6494 mL 5.2988 mL
5 mM 0.1060 mL 0.5299 mL 1.0598 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5299 mL 2.6494 mL 5.2988 mL 13.2471 mL
5 mM 0.1060 mL 0.5299 mL 1.0598 mL 2.6494 mL
10 mM 0.0530 mL 0.2649 mL 0.5299 mL 1.3247 mL
15 mM 0.0353 mL 0.1766 mL 0.3533 mL 0.8831 mL
20 mM 0.0265 mL 0.1325 mL 0.2649 mL 0.6624 mL
25 mM 0.0212 mL 0.1060 mL 0.2120 mL 0.5299 mL
30 mM 0.0177 mL 0.0883 mL 0.1766 mL 0.4416 mL
40 mM 0.0132 mL 0.0662 mL 0.1325 mL 0.3312 mL
50 mM 0.0106 mL 0.0530 mL 0.1060 mL 0.2649 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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BMS-986189 Related Classifications

Keywords:

BMS-9861891629665-96-8BMS986189BMS 986189PD-1/PD-L1PD-1/Programmed death-ligand 1PD1PD-L1Inhibitorinhibitorinhibit

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