2. Epigenetics
  3. Protein Arginine Deiminase
  4. BMS-P5

BMS-P5 is a selective and orally active peptidylarginine deiminase 4 (PAD4) inhibitor with an IC50 of 98 nM. BMS-P5 shows selective for PAD4 over PAD1, PAD2, and PAD3. BMS-P5 blocks multiple myeloma (MM)-induced neutrophil extracellular trap (NET) formation and delays progression of MM in a syngeneic mouse model.

For research use only. We do not sell to patients.

BMS-P5 Chemical Structure

BMS-P5 Chemical Structure

CAS No. : 1549811-36-0

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

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BMS-P5 Related Antibodies

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Description

BMS-P5 is a selective and orally active peptidylarginine deiminase 4 (PAD4) inhibitor with an IC50 of 98 nM. BMS-P5 shows selective for PAD4 over PAD1, PAD2, and PAD3. BMS-P5 blocks multiple myeloma (MM)-induced neutrophil extracellular trap (NET) formation and delays progression of MM in a syngeneic mouse model[1].

In Vitro

BMS-P5 blocks calcium ionophore-induced citrullination of histone H3[1].
BMS-P5 is also able to inhibit formation of NETs induced by primary MM cells isolated from the BM of patients with MM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BMS-P5 Related Antibodies

Cell Viability Assay[1]

Cell Line: Neutrophils.
Concentration: 10 µM and 100 µM.
Incubation Time: 30 min followed by addition of DP42 or 5TGM1 CM.
Result: Prevented MM-induced NET formation.
In Vivo

BMS-P5 (50 mg/kg, oral gavage) significantly improves survival of MM-bearing mice[1].
BMS-P5 (50 mg/kg, oral gavage) may attenuate the presence of pro-tumorigenic proteins in the tumor microenvironment, and thus delay tumor progression[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Syngeneic mouse model of MM[1].
Dosage: 50 mg/kg.
Administration: Oral gavage, twice a day beginning on day 3 after tumor cell injection.
Result: Significantly delayed development of symptoms and significantly prolonged survival of MM-bearing mice.
Molecular Weight

509.04

Formula

C27H33ClN6O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N1[C@@H](C)CC[C@@H](N)C1)C2=CC(OC)=C3C(N=C(C4=CC5=CC=CN=C5N4CC6CC6)N3C)=C2.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 35 mg/mL (68.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9645 mL 9.8224 mL 19.6448 mL
5 mM 0.3929 mL 1.9645 mL 3.9290 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9645 mL 9.8224 mL 19.6448 mL 49.1121 mL
5 mM 0.3929 mL 1.9645 mL 3.9290 mL 9.8224 mL
10 mM 0.1964 mL 0.9822 mL 1.9645 mL 4.9112 mL
15 mM 0.1310 mL 0.6548 mL 1.3097 mL 3.2741 mL
20 mM 0.0982 mL 0.4911 mL 0.9822 mL 2.4556 mL
25 mM 0.0786 mL 0.3929 mL 0.7858 mL 1.9645 mL
30 mM 0.0655 mL 0.3274 mL 0.6548 mL 1.6371 mL
40 mM 0.0491 mL 0.2456 mL 0.4911 mL 1.2278 mL
50 mM 0.0393 mL 0.1964 mL 0.3929 mL 0.9822 mL
60 mM 0.0327 mL 0.1637 mL 0.3274 mL 0.8185 mL
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BMS-P5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-P51549811-36-0Protein Arginine DeiminasePeptidylarginine DeiminaseMultiplemyelomaNETInhibitorinhibitorinhibit

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