2. Apoptosis
  3. Caspase
  4. Boc-Asp(OMe)-fluoromethyl ketone

Boc-Asp(OMe)-fluoromethyl ketone  (Synonyms: Boc-Asp(OMe)-FMK)

Cat. No.: HY-103348 Purity: ≥98.0%
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Boc-Asp(OME)-Fluoromethyl Ketone is a broad range caspase inhibitor that inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8.

For research use only. We do not sell to patients.

Boc-Asp(OMe)-fluoromethyl ketone Chemical Structure

Boc-Asp(OMe)-fluoromethyl ketone Chemical Structure

CAS No. : 187389-53-3

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1 mg USD 48 In-stock
5 mg USD 120 In-stock
10 mg USD 190 In-stock
25 mg USD 380 In-stock
50 mg USD 610 In-stock
100 mg USD 980 In-stock
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Based on 1 publication(s) in Google Scholar

Boc-Asp(OMe)-fluoromethyl ketone Related Antibodies

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Description

Boc-Asp(OME)-Fluoromethyl Ketone is a broad range caspase inhibitor that inhibits Fas-mediated phagocytosis and oxidative rupture inhibition, but does not affect the chemotactic activity of IL-8[1][2].

IC50 & Target[1]

Caspase

 

In Vitro

Boc-Asp(OME)-Fluoromethyl Keton (100 μM; 30 minutes; Polymorphonuclear leukocytes) prevents Fas-induced and spontaneous apoptosis (?CH-11)[1]. Boc-Asp(OME)-Fluoromethyl Keton (20 μM; 5 hours; J774.1/JA-4 cells) significantly increases LDH release[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Boc-Asp(OMe)-fluoromethyl ketone Related Antibodies
Molecular Weight

263.26

Formula

C11H18FNO5
CAS No.
Appearance

Liquid (Density: 1.15 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(OC)C[C@H](NC(OC(C)(C)C)=O)C(CF)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (379.85 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7985 mL 18.9926 mL 37.9853 mL
5 mM 0.7597 mL 3.7985 mL 7.5971 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7985 mL 18.9926 mL 37.9853 mL 94.9632 mL
5 mM 0.7597 mL 3.7985 mL 7.5971 mL 18.9926 mL
10 mM 0.3799 mL 1.8993 mL 3.7985 mL 9.4963 mL
15 mM 0.2532 mL 1.2662 mL 2.5324 mL 6.3309 mL
20 mM 0.1899 mL 0.9496 mL 1.8993 mL 4.7482 mL
25 mM 0.1519 mL 0.7597 mL 1.5194 mL 3.7985 mL
30 mM 0.1266 mL 0.6331 mL 1.2662 mL 3.1654 mL
40 mM 0.0950 mL 0.4748 mL 0.9496 mL 2.3741 mL
50 mM 0.0760 mL 0.3799 mL 0.7597 mL 1.8993 mL
60 mM 0.0633 mL 0.3165 mL 0.6331 mL 1.5827 mL
80 mM 0.0475 mL 0.2374 mL 0.4748 mL 1.1870 mL
100 mM 0.0380 mL 0.1899 mL 0.3799 mL 0.9496 mL
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Boc-Asp(OMe)-fluoromethyl ketone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Boc-Asp(OMe)-fluoromethyl ketone187389-53-3Boc-Asp(OMe)-FMKCaspaseFas-inducedspontaneousapoptosisLDHbroadoxidativeruptureInhibitorinhibitorinhibit

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