2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. Boc-C16-COOH

Boc-C16-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C16-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs

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Boc-C16-COOH Chemical Structure

Boc-C16-COOH Chemical Structure

CAS No. : 843666-40-0

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Based on 1 publication(s) in Google Scholar

Boc-C16-COOH Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Boc-C16-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C16-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs

IC50 & Target

Non-cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Boc-C16-COOH Related Antibodies
Molecular Weight

370.57

Formula

C22H42O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C)(OC(CCCCCCCCCCCCCCCCC(O)=O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (269.85 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6985 mL 13.4927 mL 26.9855 mL
5 mM 0.5397 mL 2.6985 mL 5.3971 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.98%

SDS (393 KB)

COA (238 KB) HNMR (117 KB) RP-HPLC (239 KB) MS (155 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6985 mL 13.4927 mL 26.9855 mL 67.4636 mL
5 mM 0.5397 mL 2.6985 mL 5.3971 mL 13.4927 mL
10 mM 0.2699 mL 1.3493 mL 2.6985 mL 6.7464 mL
15 mM 0.1799 mL 0.8995 mL 1.7990 mL 4.4976 mL
20 mM 0.1349 mL 0.6746 mL 1.3493 mL 3.3732 mL
25 mM 0.1079 mL 0.5397 mL 1.0794 mL 2.6985 mL
30 mM 0.0900 mL 0.4498 mL 0.8995 mL 2.2488 mL
40 mM 0.0675 mL 0.3373 mL 0.6746 mL 1.6866 mL
50 mM 0.0540 mL 0.2699 mL 0.5397 mL 1.3493 mL
60 mM 0.0450 mL 0.2249 mL 0.4498 mL 1.1244 mL
80 mM 0.0337 mL 0.1687 mL 0.3373 mL 0.8433 mL
100 mM 0.0270 mL 0.1349 mL 0.2699 mL 0.6746 mL
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Boc-C16-COOH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Boc-C16-COOH843666-40-0ADC LinkerPROTAC LinkersAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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