Bomedemstat (Synonyms: IMG-7289)

Cat. No.: HY-109169: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Bomedemstat (IMG-7289) is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. Bomedemstat can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat shows anti-cancer activities, inhibits cancer cell proliferation and induces apoptosis.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Bomedemstat hydrochloride, Bomedemstat dihydrochloride and Bomedemstat ditosylate) that retains the same biological activity.

For research use only. We do not sell to patients.

Bomedemstat Chemical Structure

CAS No. : 1990504-34-1

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MOQ		Minimum order quantity
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100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

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Other Forms of Bomedemstat:

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•Related Small Molecules:

•Related Proteins:

View All Histone Demethylase Isoform Specific Products:

View All Isoforms

KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6 KDM7

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

KDM1/LSD1

In Vitro

Bomedemstat selectively inhibits proliferation and induces apoptosis of Jak2^V617F cells by concomitantly increasing expression and methylation of p53^[1].
Bomedemstat (50 nM-1 μM; 96 h) enhances survival, induces apoptosis via BCL-XL and PUMA in a TP53-dependent manner, and leads to cell cycle arrest^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:	SET-2 cells
Concentration:	50 nM, 100 nM, and 1 μM
Incubation Time:	96 hours
Result:	Decreased levels of the antiapoptotic protein BCL-XL and increased levels of the pro-apoptotic protein PUMA.

In Vivo

Bomedemstat treatment (oral gavage; 45?mg/kg; once daily; 56 d) normalizes or improves blood cell counts, reduces spleen volumes, restores normal splenic architecture, and reduces bone marrow fibrosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mx-Jak2^V617F mice^[1]
Dosage:	45 mg/kg
Administration:	Oral gavage; 45 mg/kg; once daily; 56 days
Result:	Reduced splenomegaly significantly with a few treated mice normalizing their spleen weight, the 56-day course led to partial restoration of lymph follicles and spleen architecture by histological examination.

Clinical Trial

Molecular Weight

519.61

Formula

C₂₈H₃₄FN₇O₂

CAS No.

1990504-34-1

Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(N1CCN(CC1)C)[C@@H](NC(C2=CC=C(N3C=CN=N3)C=C2)=O)CCCN[C@H]4[C@@](C5=CC=C(C=C5)F)([H])C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (192.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9245 mL	9.6226 mL	19.2452 mL
5 mM	0.3849 mL	1.9245 mL	3.8490 mL
10 mM	0.1925 mL	0.9623 mL	1.9245 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.55%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (246 KB) HNMR (337 KB) LCMS (108 KB)

Handling Instructions (2659 KB)

References

[1]. Jonas S Jutzi,et al. LSD1 Inhibition Prolongs Survival in Mouse Models of MPN by Selectively Targeting the Disease Clone. Hemasphere.2018 Jun 8;2(3):e54. [Content Brief]

[2]. Yuan Fang, et al. LSD1/KDM1A inhibitors in clinical trials: advances and prospects. J Hematol Oncol. 2019 Dec 4;12(1):129. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9245 mL	9.6226 mL	19.2452 mL	48.1130 mL
	5 mM	0.3849 mL	1.9245 mL	3.8490 mL	9.6226 mL
	10 mM	0.1925 mL	0.9623 mL	1.9245 mL	4.8113 mL
	15 mM	0.1283 mL	0.6415 mL	1.2830 mL	3.2075 mL
	20 mM	0.0962 mL	0.4811 mL	0.9623 mL	2.4057 mL
	25 mM	0.0770 mL	0.3849 mL	0.7698 mL	1.9245 mL
	30 mM	0.0642 mL	0.3208 mL	0.6415 mL	1.6038 mL
	40 mM	0.0481 mL	0.2406 mL	0.4811 mL	1.2028 mL
	50 mM	0.0385 mL	0.1925 mL	0.3849 mL	0.9623 mL
	60 mM	0.0321 mL	0.1604 mL	0.3208 mL	0.8019 mL
	80 mM	0.0241 mL	0.1203 mL	0.2406 mL	0.6014 mL
	100 mM	0.0192 mL	0.0962 mL	0.1925 mL	0.4811 mL

Bomedemstat Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bomedemstat1990504-34-1IMG-7289IMG7289IMG 7289Histone DemethylaseApoptosisoral activitylysine-specific demethylase 1anti-cancer activityanti-proliferationinduce apoptosisSET-2Inhibitorinhibitorinhibit

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